Atorvastatin-Diltiazem Combination Induced Rhabdomyolysis Leading to Diagnosis of Hypothyroidism
Joint Authors
Ehelepola, N. D. B.
Sathkumara, S. M. B. Y.
Kaluphana, K. L. R.
Bandara, H. M. P. A. G. S.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-11
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Statins and hypothyroidism, independently, can rarely cause rhabdomyolysis.
The combination of them especially with concurrent intake of drugs such as diltiazem increases the risk of rhabdomyolysis.
Hashimoto’s encephalopathy is a rare condition associated with Hashimoto’s thyroiditis and some patients with that can present with a stroke like picture.
An elderly male who has been on atorvastatin for three years and on diltiazem for a week presented with sudden onset inability to walk and confusion.
On examination muscle tenderness was noticed and creatine kinase levels indicated rhabdomyolysis which we attributed to atorvastatin.
Patient developed a seizure and myoclonus of masseters.
Considering this, his confusion and his neutrophilia and high C-reactive protein levels, empirical antibiotics with dexamethasone were started and the patient responded to that.
His cerebrospinal fluid and blood culture reports that arrived later did not show sepsis.
After going home also his CK (creatine kinase) levels remained high; TSH (thyroid-stimulating hormone) level test was done and hypothyroidism was diagnosed.
His antithyroid peroxidase antibody levels were also very high.
We retrospectively think he had Hashimoto’s encephalopathy as well.
His lipid profile and TSH and CK values returned to normal in that order after a few months of levothyroxine therapy.
American Psychological Association (APA)
Ehelepola, N. D. B.& Sathkumara, S. M. B. Y.& Bandara, H. M. P. A. G. S.& Kaluphana, K. L. R.. 2017. Atorvastatin-Diltiazem Combination Induced Rhabdomyolysis Leading to Diagnosis of Hypothyroidism. Case Reports in Medicine،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146879
Modern Language Association (MLA)
Ehelepola, N. D. B.…[et al.]. Atorvastatin-Diltiazem Combination Induced Rhabdomyolysis Leading to Diagnosis of Hypothyroidism. Case Reports in Medicine No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1146879
American Medical Association (AMA)
Ehelepola, N. D. B.& Sathkumara, S. M. B. Y.& Bandara, H. M. P. A. G. S.& Kaluphana, K. L. R.. Atorvastatin-Diltiazem Combination Induced Rhabdomyolysis Leading to Diagnosis of Hypothyroidism. Case Reports in Medicine. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146879