Role of MicroRNA-124 as a Prognostic Factor in Multiple Neoplasms: A Meta-Analysis
Joint Authors
Yang, Hai-Wei
Li, Pengchao
Zhou, Zijian
Lv, Jiancheng
Wang, Jingzi
Yu, Hao
Lu, Hongcheng
Yuan, Baorui
Han, Jie
Zhou, Rui
Zhang, Xiaolei
Lu, Qiang
Yang, Xiao
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
MicroRNA-124 (miR-124) was revealed to be an attractive prognostic tumour biomarker in recent studies.
However, the results remain inconclusive.
Hence, this meta-analysis was carried out to clarify the precise predictive value of miR-124.
Materials and Methods.
Relevant studies were searched in PubMed, EMBASE, Web of Science, and the Cochrane Library up to October 2018.
Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were extracted from the selected studies.
Results.
A total of 29 articles investigating the correlation between miR-124 expression and prognosis were initially identified.
The pooled HR for overall survival (OS) of high miR-124 expression in multiple cancers was 0.55 (95%CI=0.50–0.61).
Disease-free survival (DFS)/progression-free survival (HR=0.48, 95%CI=0.38–0.61) revealed a protective role of increased miR-124 expression.
Epigenetic hypermethylation of miR-124 mediated the silencing of its expression, which is correlated significantly with unfavourable survival (OS: HR=2.06, 95%CI=1.68–2.53; DFS/recurrence-free survival: HR=2.77, 95%CI=1.85–4.16).
Conclusions.
Taken together, our results suggest that miR-124 plays an antioncogenic role in various tumors, such as lung cancer and colorectal cancer.
If methylation of miR-124 could be prevented, progression and metastasis would be improved; thus, miR-124 may be a promising biomarker and novel therapeutic target.
Further large-scale studies are needed to confirm this possible effect.
American Psychological Association (APA)
Zhou, Zijian& Lv, Jiancheng& Wang, Jingzi& Yu, Hao& Lu, Hongcheng& Yuan, Baorui…[et al.]. 2019. Role of MicroRNA-124 as a Prognostic Factor in Multiple Neoplasms: A Meta-Analysis. Disease Markers،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1146890
Modern Language Association (MLA)
Zhou, Zijian…[et al.]. Role of MicroRNA-124 as a Prognostic Factor in Multiple Neoplasms: A Meta-Analysis. Disease Markers No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1146890
American Medical Association (AMA)
Zhou, Zijian& Lv, Jiancheng& Wang, Jingzi& Yu, Hao& Lu, Hongcheng& Yuan, Baorui…[et al.]. Role of MicroRNA-124 as a Prognostic Factor in Multiple Neoplasms: A Meta-Analysis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1146890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146890