Alanine Aminotransferase and Body Composition in Obese Men and Women
Joint Authors
Jorde, Rolf
Bekkelund, Svein Ivar
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
There is a known relationship between serum alanine aminotransferase (ALT) and obesity in humans, but the mechanism(s) are not clarified.
This study investigated the associations between serum ALT and body composition in an overweight and obese population.
The results are based on data from a previous randomized controlled trial treating obesity with vitamin D3.
A sample of 448 overweight and obese individuals underwent dual-energy X-ray absorptiometry (DEXA) and measured serum ALT along with supplementary blood samples at study baseline.
Body fat mass and lean mass indexes were calculated by dividing total body fat/lean weight (kg) by body height squared (kg/m2).
ALT correlated with body mass index (BMI) in men but not women (r=0.33, P<0.0001 vs.
r=0.06, P=0.29).
In men, serum ALT correlated positively with fat mass index (r=0.23, P=0.004) and lean mass index (r=0.32, P<0.0001).
In women, ALT correlated with lean mass index (r=0.13, P=0.031) but not fat mass index (r=0.003, P=0.96).
In a multivariate model adjusted for age and fat mass index, a 1-unit increase in lean mass index associated with a 0.37 U/L higher ALT in the male subgroup (95% CI 0.024 to 0.040, P<0.0001).
In conclusion, serum ALT was associated with body fat mass index in men and with lean mass index in men and women in an overweight and obese population.
The findings also demonstrate a gender difference in the role of fat.
American Psychological Association (APA)
Bekkelund, Svein Ivar& Jorde, Rolf. 2019. Alanine Aminotransferase and Body Composition in Obese Men and Women. Disease Markers،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1146893
Modern Language Association (MLA)
Bekkelund, Svein Ivar& Jorde, Rolf. Alanine Aminotransferase and Body Composition in Obese Men and Women. Disease Markers No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1146893
American Medical Association (AMA)
Bekkelund, Svein Ivar& Jorde, Rolf. Alanine Aminotransferase and Body Composition in Obese Men and Women. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1146893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146893