Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases
Joint Authors
Wiggins, Claire J.
Chon, Susan Y.
Source
Case Reports in Dermatological Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-02
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
As aberrant Notch signaling has been linked to cancerous growth, Notch inhibitors represent a novel category of targeted oncological therapy.
Notch pathways in tumor cells may contribute to proliferation or limit apoptosis and differentiation.
Healthy skin differentiation and homeostasis are reliant on normal Notch expression, and disruption of this signaling has been implicated in dermatological conditions such as hidradenitis suppurativa, psoriasis, atopic dermatitis, and lichen planus.
Here, we describe two cases of patients with cutaneous side effects from Notch inhibitor treatment for adenoid cyst carcinoma (ACC) and review the role of Notch signaling in skin disease.
By illuminating connections between medication side effects and disease pathogenesis, our goal is to increase awareness of the cutaneous side effects of Notch inhibitor treatment.
American Psychological Association (APA)
Wiggins, Claire J.& Chon, Susan Y.. 2020. Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases. Case Reports in Dermatological Medicine،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1146894
Modern Language Association (MLA)
Wiggins, Claire J.& Chon, Susan Y.. Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases. Case Reports in Dermatological Medicine No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1146894
American Medical Association (AMA)
Wiggins, Claire J.& Chon, Susan Y.. Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases. Case Reports in Dermatological Medicine. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1146894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146894