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The Prognostic Value of the Expression of SMC4 mRNA in Breast Cancer
Joint Authors
Ma, Rui-min
Yang, Fan
Huang, Du-ping
Zheng, Min
Wang, Yi-luan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
To investigate the mRNA expression and clinical significance of structural maintenance of chromosomes protein 4 (SMC4) in breast cancer.
Methods.
A total of 23 paired samples were sequenced, and data from the Cancer Genome Atlas were analyzed.
Results.
SMC4 mRNA level was significantly upregulated in breast cancer tissues (P<0.001).
Patients with high mRNA expression of SMC4 had significantly poor survival (P=0.012).
Subgroup analyses show that in nontriple negative breast cancer (non-TNBC) patients, the high SMC4 mRNA expression, older age (>65), negative progesterone receptor, and advanced stages (III-IV) were independent risk factors (HR=3.293, 95% CI 1.257-8.625, P=0.015).
In patients with TNBC, high mRNA expression of SMC4 correlated with better survival rate (P<0.046).
Conclusion.
SMC4 mRNA level is a good prognostic biomarker for patients with breast cancer.
American Psychological Association (APA)
Ma, Rui-min& Yang, Fan& Huang, Du-ping& Zheng, Min& Wang, Yi-luan. 2019. The Prognostic Value of the Expression of SMC4 mRNA in Breast Cancer. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1146935
Modern Language Association (MLA)
Ma, Rui-min…[et al.]. The Prognostic Value of the Expression of SMC4 mRNA in Breast Cancer. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1146935
American Medical Association (AMA)
Ma, Rui-min& Yang, Fan& Huang, Du-ping& Zheng, Min& Wang, Yi-luan. The Prognostic Value of the Expression of SMC4 mRNA in Breast Cancer. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1146935
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146935