Gas6TAM Signaling Components as Novel Biomarkers of Liver Fibrosis

Joint Authors

Smirne, Carlo
De Benedittis, Carla
Sainaghi, Pier Paolo
Bellan, Mattia
Burlone, Michela Emma
Castello, Luigi Mario
Avanzi, Gian Carlo
Rigamonti, Cristina

Source

Disease Markers

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-09-08

Country of Publication

Egypt

No. of Pages

15

Main Subjects

Diseases

Abstract EN

Liver fibrosis consists in the accumulation of extracellular matrix components mainly derived from activated hepatic stellate cells.

This is commonly the result of chronic liver injury repair and represents an important health concern.

As liver biopsy is burdened with many drawbacks, not surprisingly there is great interest to find new reliable noninvasive methods.

Among the many are new potential fibrosis biomarkers under study, some of the most promising represented by the growth arrest-specific gene 6 (Gas6) serum protein and its family of tyrosine kinase receptors, namely, Tyro3, Axl, and MERTK (TAM).

Gas6/TAM system (mainly, Axl and MERTK) has in fact recently emerged as an important player in the progression of liver fibrosis.

This review is aimed at giving an overall perspective of the roles played by these molecules in major chronic liver diseases.

The most promising findings up to date acknowledge that both Gas6 and its receptor serum levels (such as sAxl and, probably, sMERTK) have been shown to potentially allow for easy and accurate measurement of hepatic fibrosis progression, also providing indicative parameters of hepatic dysfunction.

Although most of the current scientific evidence is still preliminary and there are no in vivo validation studies on large patient series, it still looks very promising to imagine a possible future prognostic role for these biomarkers in the multidimensional assessment of a liver patient.

One may also speculate on a potential role for this system targeting (e.g., with small molecule inhibitors against Axl) as a therapeutic strategy for liver fibrosis management, always bearing in mind that any such therapeutic approach might face toxicity.

American Psychological Association (APA)

Smirne, Carlo& Rigamonti, Cristina& De Benedittis, Carla& Sainaghi, Pier Paolo& Bellan, Mattia& Burlone, Michela Emma…[et al.]. 2019. Gas6TAM Signaling Components as Novel Biomarkers of Liver Fibrosis. Disease Markers،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1146940

Modern Language Association (MLA)

Smirne, Carlo…[et al.]. Gas6TAM Signaling Components as Novel Biomarkers of Liver Fibrosis. Disease Markers No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1146940

American Medical Association (AMA)

Smirne, Carlo& Rigamonti, Cristina& De Benedittis, Carla& Sainaghi, Pier Paolo& Bellan, Mattia& Burlone, Michela Emma…[et al.]. Gas6TAM Signaling Components as Novel Biomarkers of Liver Fibrosis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1146940

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1146940