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Hypertension Accompanied by Hyperaldosteronism, Hyperkalemia, and Hyperchloremic Acidosis: A Case Report and Literature Review
Joint Authors
Ren, Yan
Chen, Tao
Tian, Haoming
Ou, Yang
Yang, Yunyun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study reported on a 24-year-old woman who complained of a paroxysmal headache for six months and elevated blood pressure for four months.
Laboratory examination revealed increased serum potassium and chloride levels, metabolic acidosis, suppressed renin activity, and increased plasma aldosterone concentration.
Whole-exome sequencing revealed a heterozygous mutation in exon 11 of the KLHL3 gene: c.1298G > A.
After treatment with low-dose hydrochlorothiazide, her clinical problems were controlled.
This patient is the first case of Gordon syndrome (GS) within the Chinese population caused by a heterozygous KLHL3 mutation.
A systematic review of the published literature identified 27 patients with GS caused by a KLHL3 mutation.
These patients had a mean age of 28.2 ± 22.0 years; 74.1% presented with hypertension, 76.9% with hyperkalemia, and 59.1% with metabolic acidosis.
The patients also had varying levels of plasma renin activity and plasma aldosterone concentrations.
American Psychological Association (APA)
Yang, Yunyun& Ou, Yang& Ren, Yan& Tian, Haoming& Chen, Tao. 2020. Hypertension Accompanied by Hyperaldosteronism, Hyperkalemia, and Hyperchloremic Acidosis: A Case Report and Literature Review. Case Reports in Endocrinology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1146957
Modern Language Association (MLA)
Yang, Yunyun…[et al.]. Hypertension Accompanied by Hyperaldosteronism, Hyperkalemia, and Hyperchloremic Acidosis: A Case Report and Literature Review. Case Reports in Endocrinology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1146957
American Medical Association (AMA)
Yang, Yunyun& Ou, Yang& Ren, Yan& Tian, Haoming& Chen, Tao. Hypertension Accompanied by Hyperaldosteronism, Hyperkalemia, and Hyperchloremic Acidosis: A Case Report and Literature Review. Case Reports in Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1146957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146957