An Adrenocortical Carcinoma Associated with Non-Islet Cell Tumor Hypoglycemia and Aberrant ACTH Production
Joint Authors
Somasundaram, Noel
Dilrukshi, M. D. S. A.
Wickramarachchi, A. W.
Abeyaratne, D. D. K.
Shine, Brian
Jafar-Mohammadi, Bahram
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Adrenocortical carcinomas (ACCs) are infrequently reported to present with severe hypoglycemia syndrome resulting from the secretion of insulin-like growth factor II (IGF-II) by tumor cells.
Adrenocorticotropic hormone- (ACTH) independent hypercortisolism is the norm of hormonally active ACCs, but aberrant ACTH production by tumor cells can theoretically cause ACTH-dependent hypercortisolism.
The purpose of this report was to present a case of an ACC manifested with the co-occurrence of two extremely rare presentations.
Case Description.
We present a rare case of a 43-year-old male patient admitted with recurrent episodes of severe non-ketotic and non-insulin-mediated hypoglycemia due to IGF-II mediated disease and ACTH-dependent Cushing’s syndrome.
He was diagnosed with a diffusely disseminated adrenocortical carcinoma with immunohistochemistry of tumor cells showing focal ACTH immunostain positivity.
Conclusion.
Non-islet cell tumor hypoglycemia and ACTH-dependent Cushing’s syndrome are extremely rare presentations of an ACC, and co-occurrence of these entities in a single patient is never reported in the literature.
American Psychological Association (APA)
Dilrukshi, M. D. S. A.& Wickramarachchi, A. W.& Abeyaratne, D. D. K.& Shine, Brian& Jafar-Mohammadi, Bahram& Somasundaram, Noel. 2020. An Adrenocortical Carcinoma Associated with Non-Islet Cell Tumor Hypoglycemia and Aberrant ACTH Production. Case Reports in Endocrinology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1146972
Modern Language Association (MLA)
Dilrukshi, M. D. S. A.…[et al.]. An Adrenocortical Carcinoma Associated with Non-Islet Cell Tumor Hypoglycemia and Aberrant ACTH Production. Case Reports in Endocrinology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1146972
American Medical Association (AMA)
Dilrukshi, M. D. S. A.& Wickramarachchi, A. W.& Abeyaratne, D. D. K.& Shine, Brian& Jafar-Mohammadi, Bahram& Somasundaram, Noel. An Adrenocortical Carcinoma Associated with Non-Islet Cell Tumor Hypoglycemia and Aberrant ACTH Production. Case Reports in Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1146972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146972