Prognostic Value of MicroRNA-497 in Various Cancers: A Systematic Review and Meta-Analysis
Joint Authors
Wu, Shanshan
Liu, Xiaolong
Liu, Zhiqiang
Wang, Lei
Kang, Shuling
Zhao, Bixing
He, Fei
Zeng, Yongyi
Liu, Jingfeng
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Some studies showed that microRNA-497 (miR-497) might act as a prognostic biomarker of cancer.
However, the conclusion was not consistent.
The aim of this study was to investigate the prognostic role of miR-497 in various carcinomas.
Methods.
We systematically searched the databases of PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang Data to identify relevant studies.
Two independent reviewers performed the data extraction and assessed the study quality.
Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) for overall survival (OS) and disease-free survival/relapse-free survival (DFS/RFS) were used to assess the associations between miR-497 expression and cancer prognosis.
Results.
A total of 15 studies involving 1760 participants fulfilled the inclusion criteria.
The lower level of miR-497 expression was significantly associated with shorter overall survival (HR=2.19, 95% CI: 1.84-2.60).
No significant association was found between miR-497 expression and DFS/RFS in various carcinomas (HR=1.17, 95% CI: 0.53-2.57).
Subgroup analyses by ethnicity and cancer type showed the consistent results.
Conclusion.
Our studies suggested that miR-497 might be a prognostic biomarker in cancers.
However, further multicenter prospective clinical researches are needed to confirm the association between miR-497 expression and cancer prognosis.
American Psychological Association (APA)
Liu, Zhiqiang& Wu, Shanshan& Wang, Lei& Kang, Shuling& Zhao, Bixing& He, Fei…[et al.]. 2019. Prognostic Value of MicroRNA-497 in Various Cancers: A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1146974
Modern Language Association (MLA)
Liu, Zhiqiang…[et al.]. Prognostic Value of MicroRNA-497 in Various Cancers: A Systematic Review and Meta-Analysis. Disease Markers No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1146974
American Medical Association (AMA)
Liu, Zhiqiang& Wu, Shanshan& Wang, Lei& Kang, Shuling& Zhao, Bixing& He, Fei…[et al.]. Prognostic Value of MicroRNA-497 in Various Cancers: A Systematic Review and Meta-Analysis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1146974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146974