An Unusual Simultaneous Existence of Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Case Report and Review of Literature
Joint Authors
Gamboa-Domínguez, A.
Lam-Chung, César Ernesto
Rodríguez-Orihuela, Diana Lizbeth
Anda González, Jazmín De
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Synchronous parathyroid and papillary thyroid carcinoma are extremely rare.
To our knowledge, only 15 cases have been reported in the last four decades.
We describe a 50-year-old female without significant past medical or family history and no previous trauma presented with left heel pain that prompted her to seek medical attention.
Physical examination was notable for a painless nodule at the left thyroid lobe.
Laboratory evaluation showed a serum calcium level of 14.3 mg/dL (8.6–10.3 mg/dL) and intact parathyroid hormone level of 1160 pg/mL (12–88 pg/mL).
99Tc-sestamibi dual-phase with single-photon emission computed tomography fused images showed increased uptake at the left-sided inferior parathyroid gland.
Neck ultrasound showed a 1.4 cm heterogeneous nodule in the middle-third of the left thyroid gland and a solitary 1.9 cm vascularized and hypoechoic oval nodule that was considered likely to represent a parathyroid adenoma.
Due to its clinical context (severe hypercalcemia and very high levels of PTH), parathyroid carcinoma (PC) was suspected although imaging studies were not characteristic.
The patient underwent en bloc resection of the parathyroid mass and left thyroid lobe and central neck compartment dissection.
Pathology analysis revealed classical papillary thyroid carcinoma of classical subtype and parathyroid carcinoma.
Immunohistochemical staining was positive for cyclidin D1 and negative for parafibromin.
High clinical suspicion is required for parathyroid carcinoma diagnosis in the presence of very high level of parathyroid hormone, marked hypercalcemia, and the existence of any thyroid nodule should be approached and the coexistence of other carcinomas should be considered.
American Psychological Association (APA)
Lam-Chung, César Ernesto& Rodríguez-Orihuela, Diana Lizbeth& Anda González, Jazmín De& Gamboa-Domínguez, A.. 2020. An Unusual Simultaneous Existence of Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Case Report and Review of Literature. Case Reports in Endocrinology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1146983
Modern Language Association (MLA)
Lam-Chung, César Ernesto…[et al.]. An Unusual Simultaneous Existence of Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Case Report and Review of Literature. Case Reports in Endocrinology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1146983
American Medical Association (AMA)
Lam-Chung, César Ernesto& Rodríguez-Orihuela, Diana Lizbeth& Anda González, Jazmín De& Gamboa-Domínguez, A.. An Unusual Simultaneous Existence of Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Case Report and Review of Literature. Case Reports in Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1146983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146983