Links between High-Sensitivity C-Reactive Protein and Pulse Wave Analysis in Middle-Aged Patients with Hypertension and High Normal Blood Pressure
Joint Authors
Mozos, Ioana
Jianu, Daniela
Gug, Cristina
Stoian, Dana
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Arterial stiffness and arterial age provide valuable prognostic cardiovascular information.
The present study aimed at assessing the levels of vitamin D, high-sensitivity C-reactive protein (hsCRP), low-density lipoprotein cholesterol (LDL), and oxidized LDL (oxLDL) in a group of middle-aged hypertensive patients and their relationship with pulse wave velocity (PWV), central blood pressure, and early arterial aging (EAA), respectively.
A total of 56 patients, aged 48±6 years, 57% males, with hypertension and high normal blood pressure (HNBP), were investigated using a Mobile-O-Graph, to assess central and peripheral blood pressure, PWV, and arterial age.
Additionally, hsCRP, LDL, oxLDL, and 25-hydroxy vitamin D3 were assessed.
PWV, 25-hydroxy vitamin D3, hsCRP, oxLDL, and LDL levels were 7.26±0.69 m/s, 25.99±11.17 microg/l, 0.48±0.44 mg/dl, 261.37±421 ng/ml, and 145.73±39.53 mg/dl, respectively.
Significant correlations were obtained between oxLDL and pulse pressure amplification (rS=−0.347, p=0.028) and between hsCRP and LDL levels with PWV and EAA, respectively.
ROC curve analysis revealed that hsCRP is a sensitive and specific predictor of EAA and increased PWV values.
Concluding, vitamin D deficiency and increased hsCRP and LDL values are very common, and high oxidized LDL is related to pulse pressure amplification in patients with elevated blood pressure.
Vitamin D level and high-sensitivity C-reactive protein and LDL provide valuable information in middle-aged hypertensive and HNBP patients related to arterial stiffness and early arterial aging, but only hsCRP is a sensitive predictor of EAA and PWV.
American Psychological Association (APA)
Mozos, Ioana& Jianu, Daniela& Gug, Cristina& Stoian, Dana. 2019. Links between High-Sensitivity C-Reactive Protein and Pulse Wave Analysis in Middle-Aged Patients with Hypertension and High Normal Blood Pressure. Disease Markers،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1146984
Modern Language Association (MLA)
Mozos, Ioana…[et al.]. Links between High-Sensitivity C-Reactive Protein and Pulse Wave Analysis in Middle-Aged Patients with Hypertension and High Normal Blood Pressure. Disease Markers No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1146984
American Medical Association (AMA)
Mozos, Ioana& Jianu, Daniela& Gug, Cristina& Stoian, Dana. Links between High-Sensitivity C-Reactive Protein and Pulse Wave Analysis in Middle-Aged Patients with Hypertension and High Normal Blood Pressure. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1146984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146984