The Use of 99mTc-Methoxy-isobutyl-isonitrile (sestaMIBI)‎ Uptake on Scintigraphy (99m-STS)‎ in Amiodarone-Induced Thyrotoxicosis: Case Series and Review of the Literature

Abstract EN

Amiodarone is a class III antiarrhythmic drug, used by cardiologists to treat arrhythmia including atrial fibrillation (A fib) and ventricular fibrillation.

However, amiodarone is associated with endocrine dysfunction including both hypo- and hyperthyroidism.

In the literature, two types of amiodarone-induced thyrotoxicosis (AIT) were described: AIT-1 and AIT-2.

Mixed AIT also called AIT type 3 (AIT-3) has been described in the literature when the cases do not have a typical presentation.

In order to differentiate different types of AIT, various clinical, biochemical, and radiological tools have been proposed.

The use of 99mTc-methoxy-isobutyl-isonitrile (sestaMIBI) uptake on scintigraphy (99m-STS) has been suggested in the literature in only few studies (no large retrospective or prospective studies have been established in the United States).

We present a case series describing 5 patients presenting to the University of Arizona with AIT where we used 99m-STS to assess in diagnosis and treatment of different types of AIT followed by a review of the literature.