![](/images/graphics-bg.png)
Cisplatin-Induced Nephrotoxicity and HIV Associated Nephropathy: Mimickers of Myeloma-Like Cast Nephropathy
Joint Authors
Khurram, Muhammad Siddique
Alrajjal, Ahmed
Ibrar, Warda
Edens, Jacob
Sheikh, Umer
Hamza, Ameer
Qu, Hong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Myeloma cast nephropathy is an obstructing disorder of renal tubules, caused by precipitation of Bence Jones proteins.
Myeloma-like cast nephropathy (MLCN) has been reported in the literature to occur in various primary renal and nonrenal diseases.
We present a series of three rare cases of cast nephropathy, two of which are HIV patients, and the third patient is receiving cisplatin-based chemotherapy.
However, in all three patients plasma cell dyscrasia has been ruled out.
A 30-year-old male was admitted to the hospital with facial cellulitis.
The second patient is a 31-year-old male who presented with Pneumocystis jiroveci pneumonia.
The third patient was treated with cisplatin-based chemotherapy for carcinoma.
First two cases revealed foci of diffuse tubular dilatation containing hyaline casts and interstitial inflammatory infiltrate, in addition to globally sclerotic glomeruli with ultrastructural foot process fusion and mesangium expansion.
The third case showed acute tubular injury and cast formation of irregular casts composed of amorphous or granular material of low density admixed with scattered high electron-dense globules.
Myeloma-like cast nephropathy and true myeloma cast nephropathy pose similar destructive effects on renal parenchyma.
This new pattern of HIV-related nephropathy should be considered in HIV patients with MLCN, once monoclonal gammopathy is ruled out.
American Psychological Association (APA)
Khurram, Muhammad Siddique& Alrajjal, Ahmed& Ibrar, Warda& Edens, Jacob& Sheikh, Umer& Hamza, Ameer…[et al.]. 2017. Cisplatin-Induced Nephrotoxicity and HIV Associated Nephropathy: Mimickers of Myeloma-Like Cast Nephropathy. Case Reports in Nephrology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1146997
Modern Language Association (MLA)
Khurram, Muhammad Siddique…[et al.]. Cisplatin-Induced Nephrotoxicity and HIV Associated Nephropathy: Mimickers of Myeloma-Like Cast Nephropathy. Case Reports in Nephrology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1146997
American Medical Association (AMA)
Khurram, Muhammad Siddique& Alrajjal, Ahmed& Ibrar, Warda& Edens, Jacob& Sheikh, Umer& Hamza, Ameer…[et al.]. Cisplatin-Induced Nephrotoxicity and HIV Associated Nephropathy: Mimickers of Myeloma-Like Cast Nephropathy. Case Reports in Nephrology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1146997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146997