Roles of Methylated DNA Biomarkers in Patients with Colorectal Cancer
Joint Authors
Cheng, Yuen
Ma, Zhiyao
Williams, Marissa
Leung, Wai K.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Colorectal cancer (CRC) is a leading cancer globally; therefore, early diagnosis and surveillance of this cancer are of paramount importance.
Current methods of CRC diagnosis rely heavily on endoscopy or radiological imaging.
Noninvasive tests including serum detection of the carcinoembryonic antigen (CEA) and faecal occult blood testing (FOBT) are associated with low sensitivity and specificity, especially at early stages.
DNA methylation biomarkers have recently been found to have higher accuracy in CRC detection and enhanced prediction of prognosis and chemotherapy response.
The most widely studied biomarker in CRC is methylated septin 9 (SEPT9), which is the only FDA-approved methylation-based biomarker for CRC.
Apart from SEPT9, other methylated biomarkers including tachykinin-1 (TAC1), somatostatin (SST), and runt-related transcription factor 3 (RUNX3) have been shown to effectively detect CRC in a multitude of sample types.
This review will discuss the performances of various methylated biomarkers used for CRC diagnosis and monitoring, when used alone or in combination.
American Psychological Association (APA)
Ma, Zhiyao& Williams, Marissa& Cheng, Yuen& Leung, Wai K.. 2019. Roles of Methylated DNA Biomarkers in Patients with Colorectal Cancer. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1146998
Modern Language Association (MLA)
Ma, Zhiyao…[et al.]. Roles of Methylated DNA Biomarkers in Patients with Colorectal Cancer. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1146998
American Medical Association (AMA)
Ma, Zhiyao& Williams, Marissa& Cheng, Yuen& Leung, Wai K.. Roles of Methylated DNA Biomarkers in Patients with Colorectal Cancer. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1146998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146998