Cetuximab-Associated Crescentic Diffuse Proliferative Glomerulonephritis
Joint Authors
Hudali, Tamer
Manthri, Sukesh
Bandaru, Sindhura
Chang, Anthony
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-16
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Cetuximab-induced nephrotoxicity is very rare, occurring in less than 1% of colorectal cancer patients and not defined in other populations.
We report a rare case of crescentic diffuse proliferative glomerulonephritis (GN) that developed in close temporal association with cetuximab treatment.
A 65-year-old female recently completed chemotherapy with cetuximab treatment for moderately differentiated oral squamous cell carcinoma.
She was admitted with acute renal failure and nephrotic-range proteinuria.
Laboratory data showed serum creatinine of 6.6 mg/dl and urinalysis showed proteinuria, moderate hemoglobinuria, hyaline casts (41/LPF), WBC (28/HPF), and RBC (81/HPF).
Serologic studies were negative for ANA, anti-GBM, ANCA, hepatitis B, and hepatitis C.
Serum C3 and C4 level were normal.
Renal biopsy showed crescentic diffuse proliferative GN with focal features of thrombotic microangiopathy.
Patient was started on cyclophosphamide and steroids.
Her renal function did not improve on day 8 and she was started on hemodialysis.
Previous reports suggest that EGFR-targeting medications can possibly trigger or exacerbate an IgA-mediated glomerular process leading to renal failure.
This case suggests that cetuximab therapy may have triggered or exacerbated a severe glomerular injury with an unfavorable outcome.
Treating physicians should maintain a high degree of caution and monitor renal function in patients on EGFR inhibitors.
American Psychological Association (APA)
Manthri, Sukesh& Bandaru, Sindhura& Chang, Anthony& Hudali, Tamer. 2017. Cetuximab-Associated Crescentic Diffuse Proliferative Glomerulonephritis. Case Reports in Nephrology،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147013
Modern Language Association (MLA)
Manthri, Sukesh…[et al.]. Cetuximab-Associated Crescentic Diffuse Proliferative Glomerulonephritis. Case Reports in Nephrology No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1147013
American Medical Association (AMA)
Manthri, Sukesh& Bandaru, Sindhura& Chang, Anthony& Hudali, Tamer. Cetuximab-Associated Crescentic Diffuse Proliferative Glomerulonephritis. Case Reports in Nephrology. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147013