Brunner’s Gland Hyperplasia in a Patient after Roux-Y Gastric Bypass: An Important Pitfall in GLP-1 Receptor Imaging
Joint Authors
Wild, Damian
Hepprich, Matthias
Antwi, Kwadwo
Waser, Beatrice
Reubi, Jean Claude
Christ, Emanuel R.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-04
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Severe cases of postprandial hypoglycaemia after bariatric surgery can be a diagnostic and therapeutic challenge.
The diagnostic role of 68Ga-DOTA-Exendin-4 PET/CT in postbariatric hypoglycaemia for further treatment decisions is unclear.
We present a case of a 50-year-old woman with frequent and severe postprandial hypoglycaemic (≤2.5 mmol/L) episodes starting three years after Roux-Y gastric bypass.
Despite strict dietary adherence and several medical therapies, the patient remained severely affected, and 68Ga-DOTA-Exendin-4 PET/CT was performed to exclude atypical presentation of an insulinoma or nesidioblastosis.
No pancreatic abnormalities were found, but intensive tracer accumulation in the first and second part of the duodenum was detected, which proved to be hyperplastic Brunner’s glands on histology and were strongly positive for the glucagon-like peptide-1 receptor.
This case provides histopathological verification that duodenal 68Ga-DOTA-Exendin-4 uptake is caused by uptake in Brunner’s glands and points to a potential relationship between bariatric surgery and Brunner’s glands.
American Psychological Association (APA)
Hepprich, Matthias& Antwi, Kwadwo& Waser, Beatrice& Reubi, Jean Claude& Wild, Damian& Christ, Emanuel R.. 2020. Brunner’s Gland Hyperplasia in a Patient after Roux-Y Gastric Bypass: An Important Pitfall in GLP-1 Receptor Imaging. Case Reports in Endocrinology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147019
Modern Language Association (MLA)
Hepprich, Matthias…[et al.]. Brunner’s Gland Hyperplasia in a Patient after Roux-Y Gastric Bypass: An Important Pitfall in GLP-1 Receptor Imaging. Case Reports in Endocrinology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1147019
American Medical Association (AMA)
Hepprich, Matthias& Antwi, Kwadwo& Waser, Beatrice& Reubi, Jean Claude& Wild, Damian& Christ, Emanuel R.. Brunner’s Gland Hyperplasia in a Patient after Roux-Y Gastric Bypass: An Important Pitfall in GLP-1 Receptor Imaging. Case Reports in Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147019