An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease
Joint Authors
Zheng, Hao
Huang, Ping
Zhang, Li
Gu, Xiaoqiong
Liu, Yunfeng
Fu, Lanyan
Pi, Lei
Che, Di
Xu, Yufen
Long, Haifeng
Zeng, Lanlan
Yu, Tao
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Kawasaki disease (KD) is an acute vasculitis disease that commonly causes acquired heart disease in children.
Coronary artery aneurysm (CAA) is a major complication of KD.
However, the pathogenesis of KD remains unclear.
The results of a genome-wide association study (GWAS) showed that two functional single-nucleotide polymorphisms (SNPs; rs699A>G and rs5050T>G) in the angiotensinogen (AGT) gene were related to cardiovascular disease susceptibility.
The purpose of our study was to estimate the relationship between the two GWAS-identified AGT gene polymorphisms and the risk of CAA in Southern Chinese children with KD.
Methods.
We genotyped the two AGT gene polymorphisms (rs699A>G and rs5050T>G) in 760 KD cases and 972 healthy controls.
We used the odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the degree of the associations.
Results.
These two AGT gene polymorphisms were not associated with a risk of KD relative to the controls, but after adjusting for sex and age, the carriers of the rs5050G allele with TG/GG vs TT had an adjusted OR=1.56, 95% CI=1.01-2.41, and P=0.044 relative to the carriers of the rs5050TT genotype.
The susceptibility to CAA was more predominant in KD patients younger than 12 months old.
Conclusions.
Our results indicate that the AGT gene polymorphism rs5050T>G may increase the risk of CAA in children with KD, especially those who are younger than 12 months.
These results need to be verified by a validation study with a larger sample size.
American Psychological Association (APA)
Liu, Yunfeng& Fu, Lanyan& Pi, Lei& Che, Di& Xu, Yufen& Zheng, Hao…[et al.]. 2019. An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147027
Modern Language Association (MLA)
Liu, Yunfeng…[et al.]. An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1147027
American Medical Association (AMA)
Liu, Yunfeng& Fu, Lanyan& Pi, Lei& Che, Di& Xu, Yufen& Zheng, Hao…[et al.]. An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147027
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147027