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Efficiency of CAR-T Therapy for Treatment of Solid Tumor in Clinical Trials: A Meta-Analysis
Joint Authors
Li, Wen-han
Chang, Dong-min
Hou, Bin
Tang, Yao
Zeng, Qingnuo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Chimeric antigen receptor T (CAR-T) cell therapy has achieved unprecedented success among hematologic tumors, but its role in treating solid tumors is still unclear.
Methods.
A comprehensive search of electronic databases up to June 1, 2018, was carried out by two independent reviewers.
We included studies which focused on the association between CAR-T cell therapy and patient response rate and survival time in solid tumors.
Results.
22 studies with 262 patients were included in our meta-analysis.
The overall pooled response rate of CAR-T cell therapy was 9% (95% confidence interval (CI): 4-16%).
Subgroup analysis (analyses) demonstrated that CAR-T therapy could perform its best therapeutic effect on neuroblastoma, while barely works among gastrointestinal malignancies.
Moreover, the treatment efficacy was not significantly impacted by different treatment strategies (lymphodepletion before T cell infusion, transfection method, cell culture duration, persistence of CAR-T cells, transfection efficacy, total cell dose, and administration of IL-2).
Only T cell culture duration was associated with better clinical prognosis.
Conclusions.
Although CAR-T cell therapy did not have satisfactory responses in solid tumors, researchers were still holding an optimistic attitude towards its future efficacy with more modifications of its structure.
American Psychological Association (APA)
Hou, Bin& Tang, Yao& Li, Wen-han& Zeng, Qingnuo& Chang, Dong-min. 2019. Efficiency of CAR-T Therapy for Treatment of Solid Tumor in Clinical Trials: A Meta-Analysis. Disease Markers،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147053
Modern Language Association (MLA)
Hou, Bin…[et al.]. Efficiency of CAR-T Therapy for Treatment of Solid Tumor in Clinical Trials: A Meta-Analysis. Disease Markers No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1147053
American Medical Association (AMA)
Hou, Bin& Tang, Yao& Li, Wen-han& Zeng, Qingnuo& Chang, Dong-min. Efficiency of CAR-T Therapy for Treatment of Solid Tumor in Clinical Trials: A Meta-Analysis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147053