Cardiac Chagas Disease: MMPs, TIMPs, Galectins, and TGF-β as Tissue Remodelling Players
Joint Authors
Celes, Mara Rúbia Nunes
dos Reis, Marlene Antônia
da Costa, Arthur Wilson Florencio
do Carmo Neto, Jose Rodrigues
Braga, Yarlla Loyane Lira
Silva, Beatriz Aquino
Lamounier, Amanda Borges
Silva, Bárbara Oliveira
de Oliveira, Flávia Aparecida
Machado, Juliana Reis
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A century after the discovery of Chagas disease, studies are still needed to establish the complex pathophysiology of this disease.
However, it is known that several proteins and molecules are related to the establishment of this disease, its evolution, and the appearance of its different clinical forms.
Metalloproteinases and their tissue inhibitors, galectins, and TGF-β are involved in the process of infection and consequently the development of myocarditis, tissue remodeling, and fibrosis upon infection with Trypanosoma cruzi.
Thus, considering that the heart is one of the main target organs in Chagas disease, knowledge regarding the mechanisms of action of these molecules is essential to understand how they interact and trigger local and systemic reactions and, consequently, determine whether they contribute to the development of Chagas’ heart disease.
In this sense, it is believed that the inflammatory microenvironment caused by the infection alters the expression of these proteins favoring progression of the host-parasite cycle and thereby stimulating cardiac tissue remodeling mechanisms and fibrosis.
The aim of this review was to gather information on metalloproteinases and their tissue inhibitors, galectins, and TGF-β and discuss how these molecules and their different interrelationships contribute to the development of Chagas’ heart disease.
American Psychological Association (APA)
da Costa, Arthur Wilson Florencio& do Carmo Neto, Jose Rodrigues& Braga, Yarlla Loyane Lira& Silva, Beatriz Aquino& Lamounier, Amanda Borges& Silva, Bárbara Oliveira…[et al.]. 2019. Cardiac Chagas Disease: MMPs, TIMPs, Galectins, and TGF-β as Tissue Remodelling Players. Disease Markers،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1147073
Modern Language Association (MLA)
da Costa, Arthur Wilson Florencio…[et al.]. Cardiac Chagas Disease: MMPs, TIMPs, Galectins, and TGF-β as Tissue Remodelling Players. Disease Markers No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1147073
American Medical Association (AMA)
da Costa, Arthur Wilson Florencio& do Carmo Neto, Jose Rodrigues& Braga, Yarlla Loyane Lira& Silva, Beatriz Aquino& Lamounier, Amanda Borges& Silva, Bárbara Oliveira…[et al.]. Cardiac Chagas Disease: MMPs, TIMPs, Galectins, and TGF-β as Tissue Remodelling Players. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1147073
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147073