Difficult to Treat Focal, Stiff Person Syndrome of the Left Upper Extremity
Joint Authors
Esplin, Nathan E.
Stelzer, John W.
Legare, Timothy B.
Ali, Sayed K.
Source
Case Reports in Neurological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-25
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Background.
Stiff person syndrome (SPS) is a rare neurologic disorder characterized by muscle rigidity.
It is a disorder of reduced GABA activity leading to increased muscle tone and often painful spasms.
It generally presents in the axial musculature but rarely can involve only one limb, typically a lower extremity.
In rare cases it can be paraneoplastic which generally resolves on treatment of the underlying neoplasm.
Case Report.
A 46-year-old male with a history of Hodgkin’s Lymphoma in remission presented with left upper extremity pain secondary to a diagnosis of Stiff Person Syndrome limited to his left upper extremity.
He had previously benefitted from plasmapheresis and was on diazepam and baclofen at home with relatively good control of his symptoms.
SPS had previously been diagnosed with EMG and anti-GAD-65 antibody titers and was confirmed by an elevated anti-GAD-65 antibody titer.
He was treated with plasmapheresis and maximum doses of medical treatment including botulinum toxin with only transient mild improvement in his symptoms.
Conclusion.
This case represents a case of a rare disease that was refractory to all known therapies.
It outlines the need for further understanding of this disorder in order to provide better symptomatic treatment or potentially more definitive care.
American Psychological Association (APA)
Esplin, Nathan E.& Stelzer, John W.& Legare, Timothy B.& Ali, Sayed K.. 2017. Difficult to Treat Focal, Stiff Person Syndrome of the Left Upper Extremity. Case Reports in Neurological Medicine،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147106
Modern Language Association (MLA)
Esplin, Nathan E.…[et al.]. Difficult to Treat Focal, Stiff Person Syndrome of the Left Upper Extremity. Case Reports in Neurological Medicine No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1147106
American Medical Association (AMA)
Esplin, Nathan E.& Stelzer, John W.& Legare, Timothy B.& Ali, Sayed K.. Difficult to Treat Focal, Stiff Person Syndrome of the Left Upper Extremity. Case Reports in Neurological Medicine. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147106