Bioinformatic Profiling Identifies a Fatty Acid Metabolism-Related Gene Risk Signature for Malignancy, Prognosis, and Immune Phenotype of Glioma
Joint Authors
Yao, Yu
Qi, Ying
Chen, Di
Lu, Qiqi
Ji, Chunxia
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-04
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cancer cells commonly have metabolic abnormalities.
Aside from altered glucose and amino acid metabolism, cancers cells often share the attribute of fatty acid metabolic alterations.
However, fatty acid metabolism related-gene set has not been systematically investigated in gliomas.
Here, we provide a bioinformatic profiling of the fatty acid catabolic metabolism-related gene risk signature for the malignancy, prognosis and immune phenotype of glioma.
In this study, a cohort of 325 patients with whole genome RNA-seq expression data from the Chinese Glioma Genome Atlas (CGGA) dataset was used as training set, while another cohort of 667 patients from The Cancer Genome Atlas (TCGA) dataset was used as validating set.
After confirmed that fatty acid catabolic metabolism-related gene set could distinguish clinicopathological features of gliomas, we used LASSO regression analysis to develop a fatty-acid metabolism-related gene risk signature for glioma.
This 8-gene risk signature was found to be a good predictor of clinical and molecular features involved in the malignancy of gliomas.
We also identified that this 8-gene risk signature had high prognostic values in patients with gliomas.
Correlation analysis showed that our risk signature was closely associated with the immune cells involved in the microenvironment of glioma.
Furthermore, the fatty acid catabolic metabolism-related gene risk signature was also found to be significantly correlated with immune checkpoint members B7-H3 and Tim-3.
In summary, we have identified a fatty acid metabolism-related gene risk signature for malignancy, prognosis, and immune phenotype of glioma; and our study might contribute to better understanding of metabolic pathways and further developing of novel therapeutic approaches for gliomas.
American Psychological Association (APA)
Qi, Ying& Chen, Di& Lu, Qiqi& Yao, Yu& Ji, Chunxia. 2019. Bioinformatic Profiling Identifies a Fatty Acid Metabolism-Related Gene Risk Signature for Malignancy, Prognosis, and Immune Phenotype of Glioma. Disease Markers،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1147147
Modern Language Association (MLA)
Qi, Ying…[et al.]. Bioinformatic Profiling Identifies a Fatty Acid Metabolism-Related Gene Risk Signature for Malignancy, Prognosis, and Immune Phenotype of Glioma. Disease Markers No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1147147
American Medical Association (AMA)
Qi, Ying& Chen, Di& Lu, Qiqi& Yao, Yu& Ji, Chunxia. Bioinformatic Profiling Identifies a Fatty Acid Metabolism-Related Gene Risk Signature for Malignancy, Prognosis, and Immune Phenotype of Glioma. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1147147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147147