What Is the Biological Function of Uric Acid? An Antioxidant for Neural Protection or a Biomarker for Cell Death
Joint Authors
Yun, Yu
Yin, Hua
Duan, Weigang
Liu, Dequan
Yang, Dechun
Hu, Xinyu
Dong, Xianxiang
Zhang, Nan
Zhang, Lumei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The main aim of the present study was to investigate the biological function of uric acid.
The level of uric acid in different organs in normal male rats was determined with uric acid assay kits, and the expression level of genes in the organs was determined by RNA quantitative sequencing.
The correlation analysis between uric acid in the organs and gene expression (measured by FPKM value) was made.
Serum uric acid (SUA) in patients with breast cancer or with breast benign tumor was assayed when the diagnosis was made, and SUA in patients with breast cancer was also assayed just after chemotherapy.
There were 1937 mRNAs whose expression level significantly correlated with the level of uric acid, and most of which were associated with purine or nucleoside metabolism, cellular metabolism, cell cycles, and cell death pathways.
Further analysis showed that the level of uric acid was highly correlated with cell death rather than cell viability.
The level of SUA in patients with breast cancer was higher than that in patients with breast benign tumor, and the SUA increased after chemotherapy.
All the results suggested that uric acid was mainly synthesized from local nucleosides degraded from dead cells, and uric acid could be an important biomarker for cell death rather than an antioxidant for neural protection.
American Psychological Association (APA)
Liu, Dequan& Yun, Yu& Yang, Dechun& Hu, Xinyu& Dong, Xianxiang& Zhang, Nan…[et al.]. 2019. What Is the Biological Function of Uric Acid? An Antioxidant for Neural Protection or a Biomarker for Cell Death. Disease Markers،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147161
Modern Language Association (MLA)
Liu, Dequan…[et al.]. What Is the Biological Function of Uric Acid? An Antioxidant for Neural Protection or a Biomarker for Cell Death. Disease Markers No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1147161
American Medical Association (AMA)
Liu, Dequan& Yun, Yu& Yang, Dechun& Hu, Xinyu& Dong, Xianxiang& Zhang, Nan…[et al.]. What Is the Biological Function of Uric Acid? An Antioxidant for Neural Protection or a Biomarker for Cell Death. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147161