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Genome-Wide Plasma Cell-Free DNA Methylation Profiling Identifies Potential Biomarkers for Lung Cancer
Joint Authors
Lu, Jun
Wu, Jun
Zhao, Xiaodong
Xu, Wei
Zhao, Qiang
Sun, Jielin
Han, Baohui
Kang, Yani
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
As a noninvasive blood testing, the detection of cell-free DNA (cfDNA) methylation in plasma has raised an increasing interest due to diagnostic applications.
Although extensively used in cfDNA methylation analysis, bisulfite sequencing is less cost-effective.
In this study, we investigated the cfDNA methylation patterns in lung cancer patients by MeDIP-seq.
Compared with the healthy individuals, 330 differentially methylated regions (DMRs) at gene promoters were identified in lung cancer patients with 33 hypermethylated and 297 hypomethylated regions, respectively.
Moreover, these hypermethylated genes were validated with the publicly available DNA methylation data, yielding a set of ten significant differentially methylated genes in lung cancer, including B3GAT2, BCAR1, HLF, HOPX, HOXD11, MIR1203, MYL9, SLC9A3R2, SYT5, and VTRNA1-3.
Our study demonstrated MeDIP-seq could be effectively used for cfDNA methylation profiling and identified a set of potential biomarker genes with clinical application for lung cancer.
American Psychological Association (APA)
Xu, Wei& Lu, Jun& Zhao, Qiang& Wu, Jun& Sun, Jielin& Han, Baohui…[et al.]. 2019. Genome-Wide Plasma Cell-Free DNA Methylation Profiling Identifies Potential Biomarkers for Lung Cancer. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147173
Modern Language Association (MLA)
Xu, Wei…[et al.]. Genome-Wide Plasma Cell-Free DNA Methylation Profiling Identifies Potential Biomarkers for Lung Cancer. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1147173
American Medical Association (AMA)
Xu, Wei& Lu, Jun& Zhao, Qiang& Wu, Jun& Sun, Jielin& Han, Baohui…[et al.]. Genome-Wide Plasma Cell-Free DNA Methylation Profiling Identifies Potential Biomarkers for Lung Cancer. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147173