Development of Fulminant Type 1 Diabetes Mellitus in a Patient with DRESS Syndrome
Joint Authors
Perez, Pedro
Sze, Wilson
Lozeau, Daniel
Avichal, Dipa
Miller, Joshua
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also known as drug-induced hypersensitivity syndrome, is a serious, sometimes lethal, immunological reaction to drug metabolites involving multiple organ systems.
Some of the common causative agents of DRESS include allopurinol, minocycline, sulfasalazine, azathioprine, antiepileptic drugs, and hydroxychloroquine.
DRESS is often misdiagnosed and challenging to clinically manage due to the disease’s myriad presentations, acute complications, and long-term sequela after initial resolution.
We present the case of a 39-year-old female patient that developed type 1 diabetes as a sequela of DRESS.
The patient originally presented to the emergency department with three days of fevers and a pruritic erythematous maculopapular rash that began two weeks prior.
She had recently started an antibiotic course and had also been on a long-term antiepileptic drug regimen.
Following a thorough clinical examination, the patient was diagnosed with DRESS and treated accordingly.
Over the next four months, she went on to have multiple hospitalizations with several admissions to the medical intensive care unit.
She had numerous complications including significant facial edema, seizures, bacterial pneumonia, sepsis, hypovolemic shock, acute respiratory distress syndrome, diabetic ketoacidosis, nonalcoholic steatohepatitis, liver failure, and recurring DRESS rashes despite treatment with high-dose intravenous steroids and immunosuppressants.
During this time, the patient developed a rare form of uncontrolled type 1 diabetes mellitus not explained by autoantibody production or continued high-dose steroid use.
Fulminant type 1 diabetes mellitus is a sequela of DRESS that is poorly understood and rarely reported.
When it occurs, it significantly and negatively affects patient prognosis and requires careful monitoring to assure proper glycemic control.
American Psychological Association (APA)
Perez, Pedro& Sze, Wilson& Lozeau, Daniel& Avichal, Dipa& Miller, Joshua. 2020. Development of Fulminant Type 1 Diabetes Mellitus in a Patient with DRESS Syndrome. Case Reports in Endocrinology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147174
Modern Language Association (MLA)
Perez, Pedro…[et al.]. Development of Fulminant Type 1 Diabetes Mellitus in a Patient with DRESS Syndrome. Case Reports in Endocrinology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1147174
American Medical Association (AMA)
Perez, Pedro& Sze, Wilson& Lozeau, Daniel& Avichal, Dipa& Miller, Joshua. Development of Fulminant Type 1 Diabetes Mellitus in a Patient with DRESS Syndrome. Case Reports in Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147174
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147174