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Multimodal Imaging in a Patient with Hemidystonia Responsive to GPi Deep Brain Stimulation
Joint Authors
Sidiropoulos, Christos
Bowyer, Susan M.
Zillgitt, Andrew
LeWitt, Peter A.
Bagher-Ebadian, Hassan
Davoodi-Bojd, Esmaeil
Schwalb, Jason M.
Rammo, Richard
Air, Ellen
Soltanian-Zadeh, Hamid
Source
Case Reports in Neurological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-04
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Dystonia is a syndrome with varied phenomenology but our understanding of its mechanisms is deficient.
With neuroimaging techniques, such as fiber tractography (FT) and magnetoencephalography (MEG), pathway connectivity can be studied to that end.
We present a hemidystonia patient treated with deep brain stimulation (DBS).
Methods.
After 10 years of left axial hemidystonia, a 45-year-old male underwent unilateral right globus pallidus internus (GPi) DBS.
Whole brain MEG before and after anticholinergic medication was performed prior to surgery.
26-direction diffusion tensor imaging (DTI) was obtained in a 3 T MRI machine along with FT.
The patient was assessed before and one year after surgery by using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS).
Results.
In the eyes-closed MEG study there was an increase in brain coherence in the gamma band after medication in the middle and inferior frontal region.
FT demonstrated over 50% more intense ipsilateral connectivity in the right hemisphere compared to the left.
After DBS, BFMDRS motor and disability scores both dropped by 71%.
Conclusion.
Multimodal neuroimaging techniques can offer insights into the pathophysiology of dystonia and can direct choices for developing therapeutics.
Unilateral pallidal DBS can provide significant symptom control in axial hemidystonia poorly responsive to medication.
American Psychological Association (APA)
Sidiropoulos, Christos& Bowyer, Susan M.& Zillgitt, Andrew& LeWitt, Peter A.& Bagher-Ebadian, Hassan& Davoodi-Bojd, Esmaeil…[et al.]. 2017. Multimodal Imaging in a Patient with Hemidystonia Responsive to GPi Deep Brain Stimulation. Case Reports in Neurological Medicine،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147231
Modern Language Association (MLA)
Sidiropoulos, Christos…[et al.]. Multimodal Imaging in a Patient with Hemidystonia Responsive to GPi Deep Brain Stimulation. Case Reports in Neurological Medicine No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1147231
American Medical Association (AMA)
Sidiropoulos, Christos& Bowyer, Susan M.& Zillgitt, Andrew& LeWitt, Peter A.& Bagher-Ebadian, Hassan& Davoodi-Bojd, Esmaeil…[et al.]. Multimodal Imaging in a Patient with Hemidystonia Responsive to GPi Deep Brain Stimulation. Case Reports in Neurological Medicine. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147231