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KIF5A Promotes Bladder Cancer Proliferation In Vitro and In Vivo
Joint Authors
Tian, Da-Wei
Wu, Zhou-Liang
Jiang, Li-Ming
Gao, Jie
Wu, Chang-Li
Hu, Hai-Long
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Bladder cancer is a common malignancy with uncontrolled and rapid growth.
Although lots of the important regulatory networks in bladder cancer have been found, the cancer-relevant genes remain to be further identified.
Methods.
We examined the KIF5A expression levels in bladder cancer and normal bladder tissue samples via immunohistochemistry and observed the effect of KIF5A on bladder tumor cell proliferation in vitro and in vivo.
Additionally, a coexpression between KIF5A and KIF20B in tumor tissues was explored.
Results.
KIF5A expression level was higher in the bladder cancer tissues than in the adjacent nontumor tissues.
Patients with higher KIF5A expression displayed advanced clinical features and shorter survival time than those with lower KIF5A expression.
Moreover, KIF5A knockdown inhibited bladder cancer cell proliferation, migration, and invasion demonstrated in vivo and in vitro.
In addition, coexpression was found between KIF5A and KIF20B in tumor tissues.
Conclusion.
The results demonstrated that KIF5A is a critical regulator in bladder cancer development and progression, as well as a potential target in the treatment of bladder cancer.
American Psychological Association (APA)
Tian, Da-Wei& Wu, Zhou-Liang& Jiang, Li-Ming& Gao, Jie& Wu, Chang-Li& Hu, Hai-Long. 2019. KIF5A Promotes Bladder Cancer Proliferation In Vitro and In Vivo. Disease Markers،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147247
Modern Language Association (MLA)
Tian, Da-Wei…[et al.]. KIF5A Promotes Bladder Cancer Proliferation In Vitro and In Vivo. Disease Markers No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1147247
American Medical Association (AMA)
Tian, Da-Wei& Wu, Zhou-Liang& Jiang, Li-Ming& Gao, Jie& Wu, Chang-Li& Hu, Hai-Long. KIF5A Promotes Bladder Cancer Proliferation In Vitro and In Vivo. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147247
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147247