Serum Levels of miR-143 Predict Survival in Critically Ill Patients
Joint Authors
Koch, Alexander
Benz, Fabian
Roderburg, Christoph
Luedde, Mark
Vucur, Mihael
Spehlmann, Martina E.
Loosen, Sven
Rehse, Sebastian
Lurje, Georg
Luedde, Tom
Trautwein, Christian
Tacke, Frank
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background and Aims.
Recent data suggested a potential role of miR-143 as a biomarker for systemic inflammation and infection.
However, its role in critical illness and sepsis is only poorly understood.
Methods.
We determined circulating levels of miR-143 in 218 critically ill patients, of which 135 fulfilled sepsis criteria, and compared them to 76 healthy controls.
Results were correlated with clinical records.
Results.
In the total cohort of critically ill patients from a medical intensive care unit (ICU), miR-143 serum levels tended to be lower compared to healthy control samples, but this difference did not reach statistical significance.
In ICU patients, serum levels of miR-143 were independent of disease etiology, including the presence of sepsis, or severity of disease.
Importantly, low miR-143 serum levels were associated with an unfavorable short- and long-term prognosis in ICU patients.
Our study identified different optimal cut-off values at which low miR-143 serum levels predicted mortality with a high diagnostic accuracy.
In line with this, concentrations of circulating miR-143 correlated with markers of organ failure such as creatinine, bilirubin, or lactate in our cohort of critically ill patients.
Conclusion.
Low miR-143 serum levels are indicative for an unfavorable short- and long-term prognosis in critically ill patients admitted to a medical ICU.
Our data suggest a previously unrecognized role for miR-143 measurements as a novel prognostic marker in critically ill patients.
American Psychological Association (APA)
Roderburg, Christoph& Koch, Alexander& Benz, Fabian& Vucur, Mihael& Spehlmann, Martina E.& Loosen, Sven…[et al.]. 2019. Serum Levels of miR-143 Predict Survival in Critically Ill Patients. Disease Markers،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1147253
Modern Language Association (MLA)
Roderburg, Christoph…[et al.]. Serum Levels of miR-143 Predict Survival in Critically Ill Patients. Disease Markers No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1147253
American Medical Association (AMA)
Roderburg, Christoph& Koch, Alexander& Benz, Fabian& Vucur, Mihael& Spehlmann, Martina E.& Loosen, Sven…[et al.]. Serum Levels of miR-143 Predict Survival in Critically Ill Patients. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1147253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147253