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Baseline Serum sLOX-1 Concentrations Are Associated with 2-Year Major Adverse Cardiovascular and Cerebrovascular Events in Patients after Percutaneous Coronary Intervention
Joint Authors
Zhao, Zi-wen
Xu, Yi-wei
Li, Shu-mei
Guo, Jin-jian
Sun, Jian-min
Hong, Ju-chang
Chen, Liang-long
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) may be a potential biomarker of coronary artery disease (CAD) and stroke.
Objective.
We aimed to investigate the association and prognostic value of elevated sLOX-1 concentrations with regard to long-term major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with CAD undergoing primary percutaneous coronary intervention (PCI).
Methods.
A total of 1011 patients were enrolled.
Serum sLOX-1 concentrations were detected by the enzyme-linked immunosorbent assay (ELISA).
Patients were followed for 2 years.
Multivariate Cox regression and Kaplan-Meier survival curve were explored to assess the association between sLOX-1 and MACCEs.
A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of sLOX-1.
Results.
Two-year MACCEs were associated with serum sLOX-1 concentrations (HR 1.278, 95% CI 1.019-1.604, P=0.034), left main disease (HR 2.938, 95% CI 1.246-6.925, P=0.014), small-caliber stents used (HR 2.207, 95% CI 1.189-4.095, P=0.012), and total stent length (HR 1.057, 95% CI 1.005-1.112, P=0.030).
Serum sLOX-1 concentration≥1.10 ng/ml had maximum sensitivity and specificity in predicting the occurrence of 2-year MACCEs (P<0.001).
Patients with higher serum sLOX-1 concentrations showed a significantly higher incidence of MACCEs in the Kaplan-Meier curve (P<0.001).
The combination of any of the risk factors identified in multiple Cox regression was associated with a stepwise increase in MACCE rate (P<0.001).
Conclusions.
High baseline serum sLOX-1 concentration predicts 2-year MACCEs and shows an additional prognostic value to conventional risk factors in patients after primary PCI.
sLOX-1 determination might play a complementary role in the risk stratification of patients with CAD treated with PCI.
American Psychological Association (APA)
Zhao, Zi-wen& Xu, Yi-wei& Li, Shu-mei& Guo, Jin-jian& Sun, Jian-min& Hong, Ju-chang…[et al.]. 2019. Baseline Serum sLOX-1 Concentrations Are Associated with 2-Year Major Adverse Cardiovascular and Cerebrovascular Events in Patients after Percutaneous Coronary Intervention. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147280
Modern Language Association (MLA)
Zhao, Zi-wen…[et al.]. Baseline Serum sLOX-1 Concentrations Are Associated with 2-Year Major Adverse Cardiovascular and Cerebrovascular Events in Patients after Percutaneous Coronary Intervention. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1147280
American Medical Association (AMA)
Zhao, Zi-wen& Xu, Yi-wei& Li, Shu-mei& Guo, Jin-jian& Sun, Jian-min& Hong, Ju-chang…[et al.]. Baseline Serum sLOX-1 Concentrations Are Associated with 2-Year Major Adverse Cardiovascular and Cerebrovascular Events in Patients after Percutaneous Coronary Intervention. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147280