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Transcriptome Analysis of Hypertrophic Heart Tissues from Murine Transverse Aortic Constriction and Human Aortic Stenosis Reveals Key Genes and Transcription Factors Involved in Cardiac Remodeling Induced by Mechanical Stress
Joint Authors
Zou, Yunzeng
Ge, Junbo
Yu, Peng
Liu, Ming
Yang, Xue
Yu, Ying
Zhao, Ji
Jiang, Hong
Zhang, Baoli
Zhang, Chunyu
Li, Yana
Zhang, Lei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Mechanical stress-induced cardiac remodeling that results in heart failure is characterized by transcriptional reprogramming of gene expression.
However, a systematic study of genomic changes involved in this process has not been performed to date.
To investigate the genomic changes and underlying mechanism of cardiac remodeling, we collected and analyzed DNA microarray data for murine transverse aortic constriction (TAC) and human aortic stenosis (AS) from the Gene Expression Omnibus database and the European Bioinformatics Institute.
Methods and Results.
The differential expression genes (DEGs) across the datasets were merged.
The Venn diagrams showed that the number of intersections for early and late cardiac remodeling was 74 and 16, respectively.
Gene ontology and protein–protein interaction network analysis showed that metabolic changes, cell differentiation and growth, cell cycling, and collagen fibril organization accounted for a great portion of the DEGs in the TAC model, while in AS patients’ immune system signaling and cytokine signaling displayed the most significant changes.
The intersections between the TAC model and AS patients were few.
Nevertheless, the DEGs of the two species shared some common regulatory transcription factors (TFs), including SP1, CEBPB, PPARG, and NFKB1, when the heart was challenged by applied mechanical stress.
Conclusions.
This study unravels the complex transcriptome profiles of the heart tissues and highlighting the candidate genes involved in cardiac remodeling induced by mechanical stress may usher in a new era of precision diagnostics and treatment in patients with cardiac remodeling.
American Psychological Association (APA)
Yu, Peng& Zhang, Baoli& Liu, Ming& Yu, Ying& Zhao, Ji& Zhang, Chunyu…[et al.]. 2019. Transcriptome Analysis of Hypertrophic Heart Tissues from Murine Transverse Aortic Constriction and Human Aortic Stenosis Reveals Key Genes and Transcription Factors Involved in Cardiac Remodeling Induced by Mechanical Stress. Disease Markers،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1147299
Modern Language Association (MLA)
Yu, Peng…[et al.]. Transcriptome Analysis of Hypertrophic Heart Tissues from Murine Transverse Aortic Constriction and Human Aortic Stenosis Reveals Key Genes and Transcription Factors Involved in Cardiac Remodeling Induced by Mechanical Stress. Disease Markers No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1147299
American Medical Association (AMA)
Yu, Peng& Zhang, Baoli& Liu, Ming& Yu, Ying& Zhao, Ji& Zhang, Chunyu…[et al.]. Transcriptome Analysis of Hypertrophic Heart Tissues from Murine Transverse Aortic Constriction and Human Aortic Stenosis Reveals Key Genes and Transcription Factors Involved in Cardiac Remodeling Induced by Mechanical Stress. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1147299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147299