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Cytogenomic Abnormalities in 19 Cases of Salivary Gland Tumors of Parotid Gland Origin
Joint Authors
Peng, Gang
Zerjav, Marie
DiAdamo, Autumn
Grommisch, Brittany
Katherine, Amato
Chai, Hongyan
Li, Peining
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Salivary gland tumors (SGTs) of parotid origin are a group of diverse neoplasms which are difficult to classify due to their rarity and similar morphologic patterns.
Chromosome analysis can detect clonal abnormalities, and array comparative genomic hybridization (aCGH) analysis can define copy number alterations (CNAs) from tumor specimens.
Of the 19 cases of various types of SGTs submitted for cytogenomic analyses, an abnormal clone was detected in nine cases (47%), and CNAs were detected in 14 cases (74%).
Recurrent rearrangements involving the PLAG1 gene at 8q12, recurrent CNAs including deletions of 6q, 9p (CDKN2A), and 17p (TP53), loss of Y chromosome, and gain of chromosome 7 were defined from these cases.
Combined karyotyping and aCGH analyses could improve diagnostic yield.
Future study for more precisive correlation of SGT classification with cytogenomic abnormalities will facilitate better diagnosis and treatment.
American Psychological Association (APA)
Zerjav, Marie& DiAdamo, Autumn& Grommisch, Brittany& Katherine, Amato& Chai, Hongyan& Peng, Gang…[et al.]. 2020. Cytogenomic Abnormalities in 19 Cases of Salivary Gland Tumors of Parotid Gland Origin. Case Reports in Genetics،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147315
Modern Language Association (MLA)
Zerjav, Marie…[et al.]. Cytogenomic Abnormalities in 19 Cases of Salivary Gland Tumors of Parotid Gland Origin. Case Reports in Genetics No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1147315
American Medical Association (AMA)
Zerjav, Marie& DiAdamo, Autumn& Grommisch, Brittany& Katherine, Amato& Chai, Hongyan& Peng, Gang…[et al.]. Cytogenomic Abnormalities in 19 Cases of Salivary Gland Tumors of Parotid Gland Origin. Case Reports in Genetics. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147315
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147315