A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus

Abstract EN

Background.

Sevoflurane is rarely used for the treatment of status asthmaticus.

We report a case of sevoflurane hepatotoxicity in pregnancy with presentation similar to HELLP syndrome.

Case.

A G2P1001 at 23 weeks in status asthmaticus presented with pCO2 > 130 and pH < 7.

She was nonresponsive to traditional therapy.

Sevoflurane was added for a 24 hr period.

Respiratory status improved.

Extubation occurred on day 12.

Workup for preeclampsia spectrum disorders occurred due to maternal hypertension.

Given the atypical presentation and hepatotoxicity, a liver biopsy was performed.

Histologic features suggested drug induced hepatic injury.

Liver function subsequently normalized.

She delivered a term neonate without short-term complications.

Conclusion.

The use of sevoflurane is a treatment option of status asthmaticus during pregnancy.

Providers should be aware of the potential for hepatotoxicity.