The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer

Joint Authors

Sun, Jun-Jie
Li, Hong-Lin
Guo, Su-Jie
Ma, Hui
Liu, Shen-Jia
Liu, Dong
Xue, Feng-Xia

Source

Disease Markers

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-03-03

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases

Abstract EN

Cervical cancer is one of the most common malignant neoplasms in gynecology.

Protein tyrosine kinase 7 (PTK7) with an inactive kinase domain is an important regulator of multiple Wnt pathways under normal and various pathological conditions and overexpressed in various tumors; however, the clinical and biological significance of PTK7 in cervical cancer is still unknown.

In the present study, the protein expression level of PTK7 was detected in clinical cervical cancer patient samples, and the relationship between PTK7 expression and clinicopathological features was analyzed.

In addition, the Kaplan-Meier method was performed to estimate the overall survival (OS) and progression-free survival (PFS) of patients to investigate the clinicopathological significance of PTK7 expression.

Functional assays demonstrated that knocking down PTK7 might inhibit the ability of cancer cells to proliferate and invade or migrate, both in vivo and in vitro.

Thus, PTK7 might serve as a potential target for cervical cancer.

American Psychological Association (APA)

Sun, Jun-Jie& Li, Hong-Lin& Guo, Su-Jie& Ma, Hui& Liu, Shen-Jia& Liu, Dong…[et al.]. 2019. The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer. Disease Markers،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1147367

Modern Language Association (MLA)

Sun, Jun-Jie…[et al.]. The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer. Disease Markers No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1147367

American Medical Association (AMA)

Sun, Jun-Jie& Li, Hong-Lin& Guo, Su-Jie& Ma, Hui& Liu, Shen-Jia& Liu, Dong…[et al.]. The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1147367

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1147367