Serum Levels of Kisspeptin Are Elevated in Patients with Pancreatic Cancer
Joint Authors
Roderburg, Christoph
Ulmer, Florian
Luedde, Mark
Vucur, Mihael
Spehlmann, Martina E.
Loosen, Sven
Lurje, Georg
Paffenholz, Pia
Luedde, Tom
Neumann, Ulf P.
Trautwein, Christian
Tacke, Frank
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Pancreatic adenocarcinoma (PDAC) still represents a devastating disease associated with a very limited survival.
Novel biomarkers allowing an early diagnosis as well as an optimal selection of suitable treatment options for individual patients are urgently needed to improve the dismal outcome of PDAC patients.
Recently, alterations of Kisspeptin serum levels, a member of the adipokine family, were described in various types of cancers.
However, the role of circulating Kisspeptin as a biomarker in PDAC patients is poorly defined.
In this study, we measured Kisspeptin serum levels in a cohort of 128 prospectively enrolled PDAC patients undergoing surgical resection as well as 36 healthy controls.
Kisspeptin concentrations were elevated in PDAC patients compared to control samples.
Nevertheless, Kisspeptin serum levels were independent of tumor-related factors such as the tumor grading, TNM stage, or clinical features such as the ECOG performance status.
Finally, in our analysis, neither preoperative nor postoperative Kisspeptin levels turned out as a significant predictor of overall survival after tumor resection.
In conclusion, our data suggest that Kisspeptin concentrations are altered in PDAC patients but do not allow to predict patients’ outcome after resection of PDAC.
American Psychological Association (APA)
Loosen, Sven& Luedde, Mark& Lurje, Georg& Spehlmann, Martina E.& Paffenholz, Pia& Ulmer, Florian…[et al.]. 2019. Serum Levels of Kisspeptin Are Elevated in Patients with Pancreatic Cancer. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147428
Modern Language Association (MLA)
Loosen, Sven…[et al.]. Serum Levels of Kisspeptin Are Elevated in Patients with Pancreatic Cancer. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1147428
American Medical Association (AMA)
Loosen, Sven& Luedde, Mark& Lurje, Georg& Spehlmann, Martina E.& Paffenholz, Pia& Ulmer, Florian…[et al.]. Serum Levels of Kisspeptin Are Elevated in Patients with Pancreatic Cancer. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147428