PCDHGB7 Increases Chemosensitivity to Carboplatin by Inhibiting HSPA9 via Inducing Apoptosis in Breast Cancer
Joint Authors
Zhang, Ruo
Feng, Xinxin
Yang, Yongheng
Hou, Siqi
Shan, Ming
Gao, Chunyang
He, Yan
Zhang, Guoqiang
Zhang, Lei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Breast cancer is one of the most serious cancers worldwide, and chemotherapy resistance frequently drives cancer progression.
Triple-negative breast cancer (TNBC) has a high recurrence rate and poor prognosis given its resistance to chemotherapy.
In our previous study, we found a remarkable abnormal methylation modification of the PCDHGB7 gene in breast cancer.
However, the roles of PCDHGB7 in the progression and treatment of breast cancer are unclear.
In this study, we examined the effects of PCDHGB7 on the sensitivity of TNBC cells to carboplatin and investigated the underlying mechanism.
By knocking down and overexpressing PCDHGB7 in HS578T and BT549 cells, we confirmed that PCDHGB7 increases TNBC cell chemosensitivity to carboplatin.
Mechanistically, we found that PCDHGB7 negatively regulates the expression of HSPA9, uplifting its inhibition on P53 translocation and caspase-3 activation.
Thus, we demonstrated that PCDHGB7 increases chemosensitivity of TNBC cells to carboplatin by inhibiting HSPA9 via inducing apoptosis.
PCDHGB7 and HSPA9 represent potential therapeutic targets for chemosensitivity in breast cancer.
American Psychological Association (APA)
Hou, Siqi& Shan, Ming& Gao, Chunyang& Feng, Xinxin& Yang, Yongheng& Zhang, Ruo…[et al.]. 2019. PCDHGB7 Increases Chemosensitivity to Carboplatin by Inhibiting HSPA9 via Inducing Apoptosis in Breast Cancer. Disease Markers،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147526
Modern Language Association (MLA)
Hou, Siqi…[et al.]. PCDHGB7 Increases Chemosensitivity to Carboplatin by Inhibiting HSPA9 via Inducing Apoptosis in Breast Cancer. Disease Markers No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1147526
American Medical Association (AMA)
Hou, Siqi& Shan, Ming& Gao, Chunyang& Feng, Xinxin& Yang, Yongheng& Zhang, Ruo…[et al.]. PCDHGB7 Increases Chemosensitivity to Carboplatin by Inhibiting HSPA9 via Inducing Apoptosis in Breast Cancer. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147526
