Metabolic syndrome and coronary heart disease in adult patients above 45 years

Abstract EN

Objectives : to study the association between metabolic syndrome components and ischemic heart disease (IHD) in Both sexes.

Patients & Methods: A total of 1387of adult in-patients attending three different hospitals were studied.

Clinical examination and specific investigations to clarify the incidence of a central metabolic factor (body mass index BMI, high serum triglycerides TG and low high density lipoprotein HDL), a glucose factor and a blood pressure factor were carried out.

The presence of metabolic syndrome was defined as the presence of three or more risk factors.

Results : there were significant positive association between IHD defined by resting electrocardiogram (ECG) criteria and the components of metabolic syndrome including obesity, elevated blood pressure, fasting and post challenge hyperglycemia, high TG and an inverse significant association with HDL cholesterol.

Metabolic syndrome was present in 48% of studied IHD patients, with clear predominance of females 60%.

Hypertension was the commonest risk factor in both males and females (82%), obesity 57%, diabetes 20%; both more common in females.

High triglycerides present in 35%, while low HDL in 23%.

These results support the thesis that the metabolic syndrome exerts effects through different risk factors by different mechanisms.

Conclusions : the metabolic syndrome is common among ischemic heart disease patients and is related to modifiable risk factors.