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Association of Common Variants in HNF1A Gene with Serum AFP Level in Healthy Chinese Individuals and HCC Patients
Joint Authors
Li, Xue-jun
Shao, Dong-hua
He, Mei-lin
Liang, Guo-wei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Although alpha-fetoprotein (AFP) is a widely used tumor marker in hepatocellular carcinoma (HCC), 40% of newly diagnosed patients do not have an elevated AFP level.
Research has revealed that mutations in the HNF1A binding site of the AFP gene promoter cause significantly elevated serum AFP levels in patients with hereditary persistence of AFP.
This study investigated the relationship between HNF1A genetic variants and serum AFP levels.
We examined the association between the HNF1A-rs1169288 (A/C), rs2464196 (G/A), and rs1169310 (C/T) polymorphisms and AFP levels in a healthy Chinese population (n=1010) and HCC patients (n=185).
Single nucleotide polymorphisms were genotyped by the amplification refractory mutation system combined with TaqMan probe in real-time PCR.
The serum AFP concentrations were measured using the Architect i2000 immunochemistry analyzer.
In healthy individuals, serum AFP levels were significantly lower with the rs2464196-AA and rs1169310-TT genotypes.
Similar significant differences were observed in HCC patients.
Moreover, in HCC patients, the distribution frequencies of rs2464196-AA+AG and rs1169310-TT+TC among those with AFP≤20 ng/ml or ≤400 ng/ml were significantly lower than those in patients with AFP>20 ng/ml or >400 ng/ml.
Among all subjects, those carrying the HNF1A-rs2464196-A or rs1169310-T allele tended to have low levels of AFP.
However, the HNF1A-rs1169288 polymorphism showed no significant association with the serum AFP level.
These findings provide new insight into the genetic determinants of serum AFP level and can aid the differential diagnosis of HCC patients with low serum AFP.
American Psychological Association (APA)
Li, Xue-jun& Shao, Dong-hua& He, Mei-lin& Liang, Guo-wei. 2019. Association of Common Variants in HNF1A Gene with Serum AFP Level in Healthy Chinese Individuals and HCC Patients. Disease Markers،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147567
Modern Language Association (MLA)
Li, Xue-jun…[et al.]. Association of Common Variants in HNF1A Gene with Serum AFP Level in Healthy Chinese Individuals and HCC Patients. Disease Markers No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1147567
American Medical Association (AMA)
Li, Xue-jun& Shao, Dong-hua& He, Mei-lin& Liang, Guo-wei. Association of Common Variants in HNF1A Gene with Serum AFP Level in Healthy Chinese Individuals and HCC Patients. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147567