Altered Gut Microbiota Diversity and Composition in Chronic Urticaria

Joint Authors

Jiao, Xiaoyang
He, Ping
Lu, Tao
Chen, Yanxia
Guo, Yangmin
Sun, Jiayu
Shen, Weitao
Yuan, Mengsi
Zhang, Shuping

Source

Disease Markers

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-11-11

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Diseases

Abstract EN

Background.

The pathogenesis of chronic urticaria (CU) is closely related to imbalances in immunity.

The gastrointestinal microflora provides a vast and continuous stimulation for the immune system.

However, the composition and diversity of gut microflora in CU patients are rarely reported.

Methods.

10 CU patients and 10 healthy individuals were selected in this study, and their intestinal microbiome was detected by 16S rRNA sequencing.

The data were analyzed using R language software.

Results.

392 bacterial OTUs were common in the CU and healthy groups, but there were 159 OTUs particularly existing in the CU group, while 87 OTUs only were observed in healthy individuals.

The bacterial diversity was reduced in CU patients compared with healthy individuals.

The principal component analysis (PCA) and principal coordinate analysis (PCoA) revealed that the bacterial cluster in CU patients and the healthy controls were divided into different branches.

Pathogenic strains including Escherichia coli were significantly higher in CU, while Faecalibacterium prausnitzii, Prevotella copri, and Bacteroides sp.

were significantly lower in CU when compared with the healthy controls.

CU patients with a high abundance of Escherichia coli had no ideal effect for probiotic therapy.

Conclusion.

Our results demonstrated that the microbial composition was significantly different between CU patients and the healthy individual, which may be the reason leading to the various outcomes of probiotic treatment.

American Psychological Association (APA)

Lu, Tao& Chen, Yanxia& Guo, Yangmin& Sun, Jiayu& Shen, Weitao& Yuan, Mengsi…[et al.]. 2019. Altered Gut Microbiota Diversity and Composition in Chronic Urticaria. Disease Markers،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147581

Modern Language Association (MLA)

Lu, Tao…[et al.]. Altered Gut Microbiota Diversity and Composition in Chronic Urticaria. Disease Markers No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1147581

American Medical Association (AMA)

Lu, Tao& Chen, Yanxia& Guo, Yangmin& Sun, Jiayu& Shen, Weitao& Yuan, Mengsi…[et al.]. Altered Gut Microbiota Diversity and Composition in Chronic Urticaria. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147581

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1147581