Hypertrophic Cardiomyopathy: The Time-Synchronized Relationship between Ischemia and Left Ventricular Dysfunction Assessed by Highly Sensitive Troponin I and NT-proBNP
Joint Authors
Dimitrow, Pawel Petkow
Rajtar-Salwa, Renata
Gębka, Adam
Dziewierz, Artur
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to compare NT-proBNP using the absolute values and NT-proBNP/ULN values that were standardized by age and gender between three subgroups: those without ischemia (negative hs-troponin I and no anginal pain (hsTnI-/AP-)), those with painless ischemia (hsTnI+/AP-), and those with painful ischemia (hsTnI+/AP+).
Additionally, echocardiographic parameters were compared in these three subgroups.
The absolute value of NT-proBNP was significantly higher in the painful ischemia subgroup (hsTnI-/AP- vs.
hsTnI+/AP- vs.
hsTnI+/AP+: 502 (174-833) vs.
969 (363-1346) vs.
2053 (323-3283) pg/ml; p=0.018 for the whole-model analysis).
The standardized value of NT-proBNP/ULN was gradually increased (hsTnI-/AP- vs.
hsTnI+/AP- vs.
hsTnI+/AP+: 3.61+0.63 vs.
6.90+1.31 vs.
9.35+1.87; p=0.001 for the whole-model analysis).
In the comparison between subgroups (hsTnI-/AP- vs.
hsTnI+/AP- vs.
hsTnI+/AP+), two echocardiographic parameters increased significantly.
The left ventricular maximum wall thickness (LVMWT) at diastole was 1.99±0.08 cm vs.
2.28±0.13 cm vs.
2.49±0.15 cm (p=0.004 for the whole-model analysis).
The maximal gradient of the provoked left ventricular outflow tract (LVOT) gradient increased significantly in only the painful-ischemia subgroup (11 (7-30) mmHg vs.
12 (9.35-31.5) mmHg vs.
100 (43-120) mmHg).
In conclusion, both painless ischemia and painful ischemia are associated with a gradual, significant increase in NT-proBNP/ULN in comparison to the double-negative hsTnI/AP subgroup.
In contrast, NT-proBNP is significantly higher in only the subgroup with painful ischemia.
American Psychological Association (APA)
Rajtar-Salwa, Renata& Gębka, Adam& Dziewierz, Artur& Dimitrow, Pawel Petkow. 2019. Hypertrophic Cardiomyopathy: The Time-Synchronized Relationship between Ischemia and Left Ventricular Dysfunction Assessed by Highly Sensitive Troponin I and NT-proBNP. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147593
Modern Language Association (MLA)
Rajtar-Salwa, Renata…[et al.]. Hypertrophic Cardiomyopathy: The Time-Synchronized Relationship between Ischemia and Left Ventricular Dysfunction Assessed by Highly Sensitive Troponin I and NT-proBNP. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1147593
American Medical Association (AMA)
Rajtar-Salwa, Renata& Gębka, Adam& Dziewierz, Artur& Dimitrow, Pawel Petkow. Hypertrophic Cardiomyopathy: The Time-Synchronized Relationship between Ischemia and Left Ventricular Dysfunction Assessed by Highly Sensitive Troponin I and NT-proBNP. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147593