Aqueous Humor Mediator and Cytokine Aberrations in Diabetic Retinopathy and Diabetic Macular Edema: A Systematic Review and Meta-Analysis
Joint Authors
Liu, Lei
Yue, Song
Wu, Jingyang
Zhong, Yifan
Yang, Kaibo
Zhang, Guisen
Chen, Lei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Purpose.
To evaluate the relationship between the aqueous humor levels of VEGF, TNF-α, IL-10, IL-6, IL-12, MCP-1, and IP-10 with DR/DME.
Methods.
PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang databases were searched up to October 2018.
Systematic review and meta-analysis were conducted.
Results.
18 studies comprising 362 cases with DR (100 with DME) and 620 controls without DR were included in this meta-analysis.
There was a significant association between VEGF levels in the aqueous humor and DR (standardized mean difference (SMD) 1.94 (95% CI 1.05-2.83)) and DME (1.07 (0.71, 1.42)).
Furthermore, a significant correlation was observed between levels of IL-6 and DR (3.53 (0.37, 6.69)), and similarly correlation with DME (1.26 (0.30, 2.21)).
The relationship between MCP-1 and DR and DME was significant, in which the SMD was (0.49 (0.09, 0.89)) and (1.49 (0.78, 2.20)), respectively.
However, IL-12, IP-10, and TNF-α had no correlation with DR and DME, whereas there was a significant relationship between IL-8 and DME (1.68 (0.97, 2.40)).
Conclusion.
Elevated levels of VEGF, IL-6, and MCP-1 in the aqueous humor were associated with the risk for the presence of DR, and levels of VEGF, IL-6, IL-8, and MCP-1 were associated with the risk of DME.
Furthermore, these biomarkers may be used as potential predictors or therapeutic targets for DR/DME.
American Psychological Association (APA)
Wu, Jingyang& Zhong, Yifan& Yue, Song& Yang, Kaibo& Zhang, Guisen& Chen, Lei…[et al.]. 2019. Aqueous Humor Mediator and Cytokine Aberrations in Diabetic Retinopathy and Diabetic Macular Edema: A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1147619
Modern Language Association (MLA)
Wu, Jingyang…[et al.]. Aqueous Humor Mediator and Cytokine Aberrations in Diabetic Retinopathy and Diabetic Macular Edema: A Systematic Review and Meta-Analysis. Disease Markers No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1147619
American Medical Association (AMA)
Wu, Jingyang& Zhong, Yifan& Yue, Song& Yang, Kaibo& Zhang, Guisen& Chen, Lei…[et al.]. Aqueous Humor Mediator and Cytokine Aberrations in Diabetic Retinopathy and Diabetic Macular Edema: A Systematic Review and Meta-Analysis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1147619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147619