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Glutathione Transferase P1 Polymorphism Might Be a Risk Determinant in Heart Failure
Joint Authors
Simic, Tatjana
Simeunovic, Dejan
Odanovic, Natalija
Pljesa-Ercegovac, Marija
Radic, Tanja
Radovanovic, Slavica
Coric, Vesna
Milinkovic, Ivan
Matic, Marija
Djukic, Tatjana
Ristic, Arsen
Risimic, Dijana
Seferovic, Petar
Simic, Dragan
Savic-Radojevic, Ana
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Disturbed redox balance in heart failure (HF) might contribute to impairment of cardiac function, by oxidative damage, or by regulation of cell signaling.
The role of polymorphism in glutathione transferases (GSTs), involved both in antioxidant defense and in regulation of apoptotic signaling pathways in HF, has been proposed.
We aimed to determine whether GST genotypes exhibit differential risk effects between coronary artery disease (CAD) and idiopathic dilated cardiomyopathy (IDC) in HF patients.
GSTA1, GSTM1, GSTP1, and GSTT1 genotypes were determined in 194 HF patients (109 CAD, 85 IDC) and 274 age- and gender-matched controls.
No significant association was found for GSTA1, GSTM1, and GSTT1 genotypes with HF occurrence due to either CAD or IDC.
However, carriers of at least one variant GSTP1∗Val (rs1695) allele were at 1.7-fold increased HF risk than GSTP1∗Ile/Ile carriers (p=0.031), which was higher when combined with the variant GSTA1∗B allele (OR=2.2, p=0.034).
In HF patients stratified based on the underlying cause of disease, an even stronger association was observed in HF patients due to CAD, who were carriers of a combined GSTP1(rs1695)/GSTA1 “risk-associated” genotype (OR=2.8, p=0.033) or a combined GSTP1∗Ile/Val+Val/Val (rs1695)/GSTP1∗AlaVal+∗ValVal (rs1138272) genotype (OR=2.1, p=0.056).
Moreover, these patients exhibited significantly decreased left ventricular end-systolic diameter compared to GSTA1∗AA/GSTP1∗IleIle carriers (p=0.021).
Higher values of ICAM-1 were found in carriers of the GSTP1∗IleVal+∗ValVal (rs1695) (p=0.041) genotype, whereas higher TNFα was determined in carriers of the GSTP1∗AlaVal+∗ValVal genotype (rs1138272) (p=0.041).
In conclusion, GSTP1 polymorphic variants may determine individual susceptibility to oxidative stress, inflammation, and endothelial dysfunction in HF.
American Psychological Association (APA)
Simeunovic, Dejan& Odanovic, Natalija& Pljesa-Ercegovac, Marija& Radic, Tanja& Radovanovic, Slavica& Coric, Vesna…[et al.]. 2019. Glutathione Transferase P1 Polymorphism Might Be a Risk Determinant in Heart Failure. Disease Markers،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147622
Modern Language Association (MLA)
Simeunovic, Dejan…[et al.]. Glutathione Transferase P1 Polymorphism Might Be a Risk Determinant in Heart Failure. Disease Markers No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1147622
American Medical Association (AMA)
Simeunovic, Dejan& Odanovic, Natalija& Pljesa-Ercegovac, Marija& Radic, Tanja& Radovanovic, Slavica& Coric, Vesna…[et al.]. Glutathione Transferase P1 Polymorphism Might Be a Risk Determinant in Heart Failure. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147622