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Pure Testicular Seminoma Relapsing Late with Somatic Type Malignancy
Joint Authors
Dieckmann, Klaus-Peter
Anheuser, Petra
Gehrckens, Ralf
Wilczak, Waldemar
Höflmayer, Doris
Sauter, Guido
Source
Case Reports in Oncological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Somatic type malignancy (STM) occurs in 2% of all germ cell tumours (GCTs).
The prognosis is unfavourable and the origin is poorly understood.
Pathogenetic hypotheses involve direct transformation of teratoma, origin from totipotent cancer cells, or derivation from yolk sac tumour elements.
Case Presentation.
A 31-year-old patient was cured from testicular seminoma clinical stage IIc by orchiectomy and cisplatin-based chemotherapy.
Nine years later, he experienced a late relapse with a mass sized 5×6 cm located at the former metastatic site.
As no remission occurred after chemotherapy with three cycles of cisplatin, ifosfamide and etoposide, the mass was surgically resected.
Histologically, the specimen consisted of neurofibroma with areas of malignant peripheral nerve sheath tumour and spots with mature bone formation.
FISH analysis disclosed isochromosome 12p in the majority of evaluated cells suggesting somatic type malignancy (STM) of GCT.
The patient is well 1 year after surgery.
Conclusion.
The pathogenesis of this STM remains enigmatic.
The origin from GCT was evidenced by documentation of isochromosome 12p.
Unrecognized teratomatous elements in the primary and totipotent cancer cells surviving the first chemotherapy could be hypothesized to represent the origin.
STM developing from seminoma cells would be another novel hypothesis.
American Psychological Association (APA)
Dieckmann, Klaus-Peter& Anheuser, Petra& Gehrckens, Ralf& Wilczak, Waldemar& Sauter, Guido& Höflmayer, Doris. 2017. Pure Testicular Seminoma Relapsing Late with Somatic Type Malignancy. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1147631
Modern Language Association (MLA)
Dieckmann, Klaus-Peter…[et al.]. Pure Testicular Seminoma Relapsing Late with Somatic Type Malignancy. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1147631
American Medical Association (AMA)
Dieckmann, Klaus-Peter& Anheuser, Petra& Gehrckens, Ralf& Wilczak, Waldemar& Sauter, Guido& Höflmayer, Doris. Pure Testicular Seminoma Relapsing Late with Somatic Type Malignancy. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1147631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147631