Reactivation of Epstein–Barr Virus Presenting as Massive Splenomegaly after Initiation of Golimumab Treatment
Joint Authors
Febres-Aldana, Christopher A.
Medina, Ana Maria
Febres-Aldana, Anthony J.
Dvir, Kathrin
Galarza-Fortuna, Gliceida
Schwartz, Michael
Sriganeshan, Vathany
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Epstein–Barr virus infection is most commonly asymptomatic in the acute setting, where the end result of infection is the adoption of a viral latency phenotype.
The virus can reactivate later in life leading to the abnormal proliferation of the infected B, T, or NK cells.
Hereby, we report a 71-year-old female with seronegative rheumatoid arthritis who presented with massive splenomegaly, pancytopenia, and positivization of antibodies against double-stranded deoxyribonucleic acid (dsDNA) after initiation of the anti-tumor necrosis factor (TNF) golimumab.
The diagnosis of EBV-associated lymphoproliferative disorder (LPD) was demonstrated by elevation of the plasmatic EBV viral load.
Withdrawal of the anti-TNF and treatment with the anti-CD20 antibody rituximab were able to revert the clinical abnormalities.
EBV-associated LPDs are described after initiation of other anti-TNF agents, such as infliximab, but no reports of golimumab-associated EBV LPD are found in the literature.
The mechanisms for this occurrence are not clear, but these are known to involve expression of a panel of viral proteins specific to the viral latency phenotypes.
American Psychological Association (APA)
Febres-Aldana, Anthony J.& Febres-Aldana, Christopher A.& Dvir, Kathrin& Galarza-Fortuna, Gliceida& Schwartz, Michael& Medina, Ana Maria…[et al.]. 2020. Reactivation of Epstein–Barr Virus Presenting as Massive Splenomegaly after Initiation of Golimumab Treatment. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147643
Modern Language Association (MLA)
Febres-Aldana, Anthony J.…[et al.]. Reactivation of Epstein–Barr Virus Presenting as Massive Splenomegaly after Initiation of Golimumab Treatment. Case Reports in Hematology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1147643
American Medical Association (AMA)
Febres-Aldana, Anthony J.& Febres-Aldana, Christopher A.& Dvir, Kathrin& Galarza-Fortuna, Gliceida& Schwartz, Michael& Medina, Ana Maria…[et al.]. Reactivation of Epstein–Barr Virus Presenting as Massive Splenomegaly after Initiation of Golimumab Treatment. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147643
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147643