Use of KRD-PACE as Salvage Therapy in Aggressive, RelapsedBortezomib-Refractory Extramedullary Multiple Myeloma: A Report of Two Cases and Literature Review
Joint Authors
Ailawadhi, Sikander
Sher, Taimur
Parrondo, Ricardo D.
Alegria, Victoria
Chanan-Khan, Asher A.
Roy, Vivek
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Extramedullary multiple myeloma is defined by the presence of plasma cell infiltration outside of the bone marrow.
It is associated with a poor prognosis and resistance to therapy and is often associated with high-risk cytogenetics.
Aggressive relapsed and refractory extramedullary multiple myeloma is often treated with salvage infusional chemotherapy to achieve rapid disease control.
Commonly used regimens include DCEP, CVAD, and VTD-PACE.
While VTD-PACE contains bortezomib and thalidomide which have potent antimyeloma activity, the advent of novel agent therapy with proteasome inhibitors and immunomodulatory agents being used in the first-line setting has resulted in many patients being refractory to bortezomib by the time they are treated with VTD-PACE.
Herein, we discuss two cases of aggressive relapsed, high-risk, bortezomib-refractory extramedullary multiple myeloma treated with KRD-PACE and review the available clinical data on salvage chemotherapy regimens used in relapsed refractory myeloma.
American Psychological Association (APA)
Parrondo, Ricardo D.& Roy, Vivek& Sher, Taimur& Alegria, Victoria& Chanan-Khan, Asher A.& Ailawadhi, Sikander. 2020. Use of KRD-PACE as Salvage Therapy in Aggressive, RelapsedBortezomib-Refractory Extramedullary Multiple Myeloma: A Report of Two Cases and Literature Review. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147658
Modern Language Association (MLA)
Parrondo, Ricardo D.…[et al.]. Use of KRD-PACE as Salvage Therapy in Aggressive, RelapsedBortezomib-Refractory Extramedullary Multiple Myeloma: A Report of Two Cases and Literature Review. Case Reports in Hematology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1147658
American Medical Association (AMA)
Parrondo, Ricardo D.& Roy, Vivek& Sher, Taimur& Alegria, Victoria& Chanan-Khan, Asher A.& Ailawadhi, Sikander. Use of KRD-PACE as Salvage Therapy in Aggressive, RelapsedBortezomib-Refractory Extramedullary Multiple Myeloma: A Report of Two Cases and Literature Review. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147658
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147658