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Advanced Alveolar Soft Part Sarcoma Treated with Pazopanib over Three Years
Joint Authors
Shido, Yoji
Matsuyama, Yukihiro
Source
Case Reports in Oncological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Alveolar soft part sarcoma (ASPS) is a rare malignant tumor that generally occurs in adolescents and young adults.
It progresses slowly, but lung and brain metastases often occur in the early phase of the clinical course, and chemotherapy has been reported as not being effective for ASPS.
Pazopanib is a multitargeted tyrosine kinase inhibitor that has been clinically available from November 2012 in Japan.
This is a case report of a patient presented with multiple lung metastases and unresectable primary abdominal ASPS.
We initially treated this patient by systemic chemotherapy with combination use of ifosfamide and doxorubicin.
Stable disease was observed without any objective response.
Then, we finally started to administrate pazopanib 800 mg/day.
After 25 months of pazopanib administration, slight tumor reduction and a decrease of enhancement were observed.
Objective responses were achieved for both the primary tumor and metastatic lung tumor; however, a newly developed brain metastasis was subsequently identified.
Based on this case, pazopanib appears effective against ASPS, except for brain metastases.
This case suggests that pazopanib may be useful as a first-line drug against unresectable ASPS and that longitudinal assessment of brain metastasis should be performed in similar cases.
American Psychological Association (APA)
Shido, Yoji& Matsuyama, Yukihiro. 2017. Advanced Alveolar Soft Part Sarcoma Treated with Pazopanib over Three Years. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147659
Modern Language Association (MLA)
Shido, Yoji& Matsuyama, Yukihiro. Advanced Alveolar Soft Part Sarcoma Treated with Pazopanib over Three Years. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1147659
American Medical Association (AMA)
Shido, Yoji& Matsuyama, Yukihiro. Advanced Alveolar Soft Part Sarcoma Treated with Pazopanib over Three Years. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147659