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Small Split Doses of CD34+ Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy
Joint Authors
Yankelevich, Maxim
Savasan, Sureyya
Dolgopolov, Igor
Chu, Roland
Mentkevich, George
Source
Case Reports in Oncological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Cumulative myelosuppression is the main limiting factor for administration of repeated cycles of chemotherapy.
We present a case series of five pediatric patients with high-risk solid malignancies who received small split peripheral blood stem cells (PBSC) doses of less than 1 × 106/kg CD34+ cells obtained after a single leukapheresis procedure and given after repeated cycles of ICE (ifosfamide, carboplatin, and etoposide) chemotherapy.
Mean duration to absolute neutrophil count (ANC) recovery to >1000/mm3 and platelet recovery to >50 × 103/mm3 was 17.1 and 24.3 days.
Using split doses of PBSC prevented prolonged neutropenia after repeated cycles of submyeloablative chemotherapy.
American Psychological Association (APA)
Yankelevich, Maxim& Savasan, Sureyya& Dolgopolov, Igor& Chu, Roland& Mentkevich, George. 2017. Small Split Doses of CD34+ Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147660
Modern Language Association (MLA)
Yankelevich, Maxim…[et al.]. Small Split Doses of CD34+ Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1147660
American Medical Association (AMA)
Yankelevich, Maxim& Savasan, Sureyya& Dolgopolov, Igor& Chu, Roland& Mentkevich, George. Small Split Doses of CD34+ Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147660
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147660