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Squamous Cell Carcinoma of the Thyroid as a Result of Anaplastic Transformation from BRAF-Positive Papillary Thyroid Cancer
Joint Authors
Alina, Basnet
Pandita, Aakriti
Fullmer, Joseph
Sivapiragasam, Abirami
Source
Case Reports in Oncological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of the thyroid.
Majority of the PTC carries an excellent prognosis.
However, patients with tall cell variant (TCV) of papillary thyroid carcinoma have a worse prognosis than those with the classic variant.
On the other hand, squamous cell carcinoma of the thyroid (SCT) is an unusual neoplasm thought to arise as a primary tumor or as a component of an anaplastic or undifferentiated carcinoma.
We report a patient with TCV of PTC presenting years later with squamous transformation.
In addition, the patient was found to have BRAF mutation.
Such dedifferentiation is considered to be a rare phenomenon and has been reported only in the form of case reports in the literature.
The relationship between BRAFV600E mutation and squamous cell transformation of papillary thyroid cancer is unknown at this time.
Meticulous pathology is needed to identify such variants.
Our patient responded to treatment with concurrent chemotherapy with carboplatin and paclitaxel along with radiation.
American Psychological Association (APA)
Alina, Basnet& Pandita, Aakriti& Fullmer, Joseph& Sivapiragasam, Abirami. 2017. Squamous Cell Carcinoma of the Thyroid as a Result of Anaplastic Transformation from BRAF-Positive Papillary Thyroid Cancer. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147662
Modern Language Association (MLA)
Alina, Basnet…[et al.]. Squamous Cell Carcinoma of the Thyroid as a Result of Anaplastic Transformation from BRAF-Positive Papillary Thyroid Cancer. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1147662
American Medical Association (AMA)
Alina, Basnet& Pandita, Aakriti& Fullmer, Joseph& Sivapiragasam, Abirami. Squamous Cell Carcinoma of the Thyroid as a Result of Anaplastic Transformation from BRAF-Positive Papillary Thyroid Cancer. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147662