Immune Thrombocytopenic Purpura (ITP) as an Uncommon Extraintestinal Complication of Crohn’s Disease: Case Vignette and Systematic Literature Review
Joint Authors
Lee, Jennifer
Epistola, Raisa
Do, Tiffanie
Vankina, Ritika
Wu, Daniel
Fleischman, Michael W.
Yeh, James
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
While the association of immune thrombocytopenic purpura (ITP) and inflammatory bowel disease (IBD) has been described in a few case reports, management of ITP as an extraintestinal manifestation of Crohn’s disease (CD) is less studied.
There are approximately a dozen cases describing the management of patients dually diagnosed with CD/ITP.
Previous reports postulated that the mechanism of ITP in CD was through the presence of circulating immune complexes in the serum and antigenic mimicry due to increased mucosal permeability in active colitis, versus increased mucosal production of TH1-type proinflammatory cytokines during CD flares, which may account for remission of ITP with surgery for CD.
We present a case of a 27-year-old man who presented with medically refractory CD and ITP who responded to surgical management with colectomy and splenectomy, along with a systematic review of the literature.
These cases suggest that colectomy should be considered in the treatment of medically refractory ITP among patients with concomitant CD.
American Psychological Association (APA)
Epistola, Raisa& Do, Tiffanie& Vankina, Ritika& Wu, Daniel& Yeh, James& Fleischman, Michael W.…[et al.]. 2020. Immune Thrombocytopenic Purpura (ITP) as an Uncommon Extraintestinal Complication of Crohn’s Disease: Case Vignette and Systematic Literature Review. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147663
Modern Language Association (MLA)
Epistola, Raisa…[et al.]. Immune Thrombocytopenic Purpura (ITP) as an Uncommon Extraintestinal Complication of Crohn’s Disease: Case Vignette and Systematic Literature Review. Case Reports in Hematology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1147663
American Medical Association (AMA)
Epistola, Raisa& Do, Tiffanie& Vankina, Ritika& Wu, Daniel& Yeh, James& Fleischman, Michael W.…[et al.]. Immune Thrombocytopenic Purpura (ITP) as an Uncommon Extraintestinal Complication of Crohn’s Disease: Case Vignette and Systematic Literature Review. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147663
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147663