Hemophagocytic Lymphohistiocytosis (HLH) in a Patient with Disseminated Histoplasmosis
Joint Authors
Swaminathan, Neeraja
Vinicius, Jorge M.
Serrins, Jesse
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Hemophagocytic lymphohistiocytosis (HLH) is a rare condition characterized by an overwhelming inflammatory cascade activation which is often associated with rapid progression and high mortality.
It may be familial with an underlying genetic mutation or triggered by infection, malignancy, and autoimmune disease.
Disseminated histoplasmosis caused by histoplasma capsulatum is a granulomatous fungal disease seen typically in immunocompromised patients with varied clinical manifestations and requires long-term antifungal therapy.
We present the case of a 61-year-old immunocompromised female with significant travel history who came with fever, pancytopenia, and liver failure raising suspicion for HLH that prompted a bone marrow biopsy procedure.
Hemophagocytic figures consistent with HLH and numerous encapsulated fungi resembling histoplasma were visualized.
She was treated with intravenous (IV) liposomal amphotericin B.
Etoposide chemotherapy and interleukin-1 (IL-1) antagonist anakinra were deferred in order to limit her immunosuppression, and treatment was focused on antifungal therapy.
American Psychological Association (APA)
Swaminathan, Neeraja& Vinicius, Jorge M.& Serrins, Jesse. 2020. Hemophagocytic Lymphohistiocytosis (HLH) in a Patient with Disseminated Histoplasmosis. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147668
Modern Language Association (MLA)
Swaminathan, Neeraja…[et al.]. Hemophagocytic Lymphohistiocytosis (HLH) in a Patient with Disseminated Histoplasmosis. Case Reports in Hematology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1147668
American Medical Association (AMA)
Swaminathan, Neeraja& Vinicius, Jorge M.& Serrins, Jesse. Hemophagocytic Lymphohistiocytosis (HLH) in a Patient with Disseminated Histoplasmosis. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147668