Recurrent Gastrointestinal Hemorrhage in Children with Philadelphia-Positive B-Cell Acute Lymphoblastic Leukemia Treated with Dasatinib: Case Reports
Joint Authors
Liao, Xin
Guo, Yuxia
Shen, Yali
Xiao, Jianwen
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Dasatinib, a second-line tyrosine kinase inhibitor (TKI), has been widely used in chronic myeloid leukemia (CML) and Philadelphia-positive B-cell acute lymphoblastic leukemia (Ph + B-ALL).
Although dasatinib has been well tolerated, side effects including hemorrhage are not rare.
Cases of bleeding disorders ultimately result in thrombocytopenia, but platelet aggregation dysfunction induced by dasatinib has also been demonstrated in Ph + B-ALL and CML patients.
We report three Chinese children with Ph + B-ALL who received a combination treatment of chemotherapy and dasatinib and developed gastrointestinal bleeding several months later.
The platelet count and clotting tests were normal, and these patients presented with dasatinib-induced platelet dysfunction.
These findings reveal that physicians should be aware of and carefully monitor for side effects, including bleeding disorders.
American Psychological Association (APA)
Liao, Xin& Guo, Yuxia& Shen, Yali& Xiao, Jianwen. 2020. Recurrent Gastrointestinal Hemorrhage in Children with Philadelphia-Positive B-Cell Acute Lymphoblastic Leukemia Treated with Dasatinib: Case Reports. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147670
Modern Language Association (MLA)
Liao, Xin…[et al.]. Recurrent Gastrointestinal Hemorrhage in Children with Philadelphia-Positive B-Cell Acute Lymphoblastic Leukemia Treated with Dasatinib: Case Reports. Case Reports in Hematology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1147670
American Medical Association (AMA)
Liao, Xin& Guo, Yuxia& Shen, Yali& Xiao, Jianwen. Recurrent Gastrointestinal Hemorrhage in Children with Philadelphia-Positive B-Cell Acute Lymphoblastic Leukemia Treated with Dasatinib: Case Reports. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147670