Association between MicroRNA-4669 Polymorphism and Ischemic Stroke in a Korean Population
Joint Authors
Park, Hae Jeong
Hong, Seoung-Jin
Kim, Su Kang
Yun, Dong Hwan
Chon, Jinmann
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Recent studies have explored the association between single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) and ischemic stroke (IS).
In particular, the associations of rs2910164 (miRNA-146A), rs11614913 (miRNA-196A2), and rs3746444 (miRNA-499A) were intensively studied in IS.
In this study, we investigated the associations between SNPs in miRNAs and IS including rs2910164, rs11614913, and rs3746444 in a Korean population.
For a pilot study, we selected 19 SNPs in pre-miRNA region (including mature miRNA region) and genotyped in 140 IS patients and 240 control subjects using the Fluidigm Dynamic Array.
Our pilot study showed a weak association of rs79402775 in miRNA-933 (p=0.044) and a relatively strong association of rs35196866 in miRNA-4669 (p=0.016) with IS.
From the pilot study, we selected rs79402775, rs35196866, and rs7202008 (miRNA-2117; p=0.055) as candidate miRNA SNPs on IS and further genotyped these SNPs in 264 IS patients and 455 control subjects using direct sequencing.
In addition, we further analyzed the associations of rs2910164, rs11614913, and rs3746444 that have been intensively studied in previous studies.
In the further analysis, we found the significant association between rs35196866 and IS (p=0.0014 in additive model and p=0.00015 in dominant model; p=0.00037 in allele frequency analysis).
However, the association between rs2910164, rs11614913, rs3746444, rs79402775, and rs7202008 and IS was not shown.
These results suggest that miRNA-4669 may be involved in the susceptibility of IS.
American Psychological Association (APA)
Hong, Seoung-Jin& Kim, Su Kang& Yun, Dong Hwan& Chon, Jinmann& Park, Hae Jeong. 2019. Association between MicroRNA-4669 Polymorphism and Ischemic Stroke in a Korean Population. Disease Markers،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147685
Modern Language Association (MLA)
Hong, Seoung-Jin…[et al.]. Association between MicroRNA-4669 Polymorphism and Ischemic Stroke in a Korean Population. Disease Markers No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1147685
American Medical Association (AMA)
Hong, Seoung-Jin& Kim, Su Kang& Yun, Dong Hwan& Chon, Jinmann& Park, Hae Jeong. Association between MicroRNA-4669 Polymorphism and Ischemic Stroke in a Korean Population. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147685
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147685